{"id":"W4392888299","doi":"10.1016/j.bpj.2024.03.018","title":"Testing the feasibility of targeting a conserved region on the S2 domain of the SARS-CoV-2 spike protein","year":2024,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"Genome British Columbia; University of British Columbia","funders":"University of British Columbia; Mitacs; Canadian Institutes of Health Research; Digital Technology Supercluster; Western Canada Research Grid; Compute Canada","keywords":"Epitope; Immunogen; Biology; Computational biology; Biophysics; Virology; Genetics; Antibody","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008872945,0.0003699074,0.0002126313,0.0001136673,0.0003839594,0.0004892787,0.0004281729,0.001020693,0.001605197],"category_scores_gemma":[0.0008354142,0.0001800031,0.0002778895,0.000100366,0.0004943233,0.0004935871,0.0002706024,0.0008021635,0.0003157977],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004181813,"about_ca_system_score_gemma":0.0004777197,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001531828,"about_ca_topic_score_gemma":0.001250097,"domain_scores_codex":[0.9995453,0.0001283133,0.00003268678,0.00009370007,0.0001071749,0.00009290202],"domain_scores_gemma":[0.9996583,0.0001766279,0.00004415107,0.0000308759,0.00004670568,0.00004329091],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008286927,0.0005608692,0.0003633017,0.00002495332,0.000007886884,0.00005877365,0.00004590661,0.0004104393,0.9965913,0.0001668551,0.00004635432,0.0008946527],"study_design_scores_gemma":[0.0003914198,0.008259264,0.001476189,0.000004346892,0.00003484941,0.0001943529,0.00009605107,0.005933624,0.9822334,0.0001354584,0.001227516,0.00001342241],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977336,0.00005940621,0.001478967,0.00009071255,0.00002482622,0.00006762794,0.00007005037,0.00001455291,0.0004602025],"genre_scores_gemma":[0.995669,0.00008477761,0.002918204,0.00008803404,0.000007717231,0.00006244984,0.0001888037,0.00001365085,0.0009673989],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001605197,"threshold_uncertainty_score":0.005369842,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1305281307762303,"score_gpt":0.3672781735471246,"score_spread":0.2367500427708943,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}