{"id":"W4392891601","doi":"10.1101/2024.03.16.585039","title":"Biomimetic fractal topography enhances podocyte maturation in vitro","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Single-cell and spatial transcriptomics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Heart and Stroke Foundation; McMaster University; St. Joseph’s Healthcare Hamilton; National Research Council Canada; University of Alberta; Toronto General Hospital; University of Toronto; University Health Network","funders":"","keywords":"Fractal dimension; Fractal; Cell biology; Cell; Biology; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003102286,0.0005127319,0.0004153977,0.0003394287,0.00007002198,0.0002325265,0.0004235853,0.0007666198,0.00001306987],"category_scores_gemma":[0.00006039209,0.0005427013,0.0002673771,0.0004021299,0.0001186853,0.000009027444,0.0003417497,0.0006001985,0.00003282981],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007496272,"about_ca_system_score_gemma":0.0003296527,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008127579,"about_ca_topic_score_gemma":0.0000151883,"domain_scores_codex":[0.9976356,0.000102408,0.0004997554,0.001063808,0.0002367471,0.0004616589],"domain_scores_gemma":[0.9987491,0.0000156821,0.000175155,0.0007648762,0.0001519605,0.0001431645],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002511623,0.0001154138,0.0004346878,0.0002952712,0.0001161054,0.00003284968,0.000007281112,0.00001801763,0.9985327,0.00003541846,0.0001507763,0.0000103607],"study_design_scores_gemma":[0.0003339098,0.00007205412,0.005824071,0.0001949053,0.00007177608,3.017367e-8,0.000002394885,0.0002474342,0.9889042,0.000009537099,0.003719112,0.0006205637],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906566,0.005708989,0.0005909028,0.0001525273,0.002094515,0.0004533813,0.0002013561,0.0001153829,0.0000263773],"genre_scores_gemma":[0.9958163,0.0006852155,0.002293519,0.0001775875,0.0007830015,0.0001123973,0.000006297534,0.000114705,0.00001097454],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009628444,"threshold_uncertainty_score":0.9997025,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00834066455279495,"score_gpt":0.2134706226770965,"score_spread":0.2051299581243015,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}