{"id":"W4392895670","doi":"10.1128/mbio.02424-23","title":"Redefining development in <i>Streptomyces venezuelae</i> : integrating exploration into the classical sporulating life cycle","year":2024,"lang":"en","type":"article","venue":"mBio","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Streptomyces; Biology; Cell envelope; Mutant; Sigma factor; Streptomyces albus; Cell biology; Genetics; Microbiology; Bacteria; Gene; Escherichia coli","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008116306,0.0003397191,0.0001461802,0.0001788921,0.0001767173,0.0003111808,0.0001983587,0.0001419948,0.000565015],"category_scores_gemma":[0.0001526053,0.00009315375,0.0001290792,0.0001419071,0.0001932981,0.0001554919,0.0004254356,0.0003445448,0.0001282549],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003223535,"about_ca_system_score_gemma":0.0003106857,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002335603,"about_ca_topic_score_gemma":0.003667433,"domain_scores_codex":[0.9999347,0.00001218278,0.0000053332,0.00001418196,0.00001336451,0.00002026034],"domain_scores_gemma":[0.9998925,0.0000226876,0.00003349306,0.00001358156,0.000008413896,0.0000292827],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005801828,0.00002038193,0.0009251648,0.00001613851,0.000001326439,0.00005886195,0.00002676282,0.00009731387,0.9973246,0.00007527323,0.00001523505,0.001380927],"study_design_scores_gemma":[0.00002039621,0.0005910308,0.06567613,0.00001768495,0.00001620372,0.0006552167,0.0003465323,0.003252388,0.9251665,0.0002061749,0.004023259,0.00002841313],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977691,0.0001276667,0.001149066,0.0000232647,0.000005828752,0.00001129693,0.00009995213,0.00004835647,0.0007655243],"genre_scores_gemma":[0.9976846,0.0000794575,0.001286264,0.000009143439,0.000001708277,0.000009095961,0.000148747,0.00001336689,0.0007675878],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002335603,"threshold_uncertainty_score":0.004644036,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02366347331574292,"score_gpt":0.2664850027761901,"score_spread":0.2428215294604472,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}