{"id":"W4392902402","doi":"10.1016/j.jacc.2023.12.034","title":"Genetic Factors Altering Immune Responses in Atrial Fibrillation","year":2024,"lang":"en","type":"article","venue":"Journal of the American College of Cardiology","topic":"IL-33, ST2, and ILC Pathways","field":"Immunology and Microbiology","cited_by":23,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute of Infection and Immunity; Montreal Heart Institute; Université de Montréal","funders":"Canadian Institutes of Health Research; Fédération Française de Cardiologie; Fondation pour la Recherche Médicale; Institut de Cardiologie de Montréal; Servier; Fondation Leducq; Agence Nationale de la Recherche; Institut Servier; European Genomic Institute for Diabetes; Heart and Stroke Foundation of Canada","keywords":"Medicine; Epigenetics; Innate immune system; Atrial fibrillation; Immune system; Immunology; Proinflammatory cytokine; Phenotype; Myeloid; Bioinformatics; Inflammation; Genetics; Gene; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004832991,0.0001347131,0.0007262445,0.000295895,0.00006140867,0.000004713798,0.0002732533,0.00009787353,0.00001179865],"category_scores_gemma":[0.0003883453,0.00008899186,0.000515068,0.0004087333,0.0004209509,0.00005799164,0.00009040797,0.0003231828,0.000008473719],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008095775,"about_ca_system_score_gemma":0.0003151615,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003689606,"about_ca_topic_score_gemma":0.000007419847,"domain_scores_codex":[0.9981394,0.0008125062,0.0006312272,0.0001314877,0.00005503881,0.0002303351],"domain_scores_gemma":[0.9986625,0.0006052852,0.0004266495,0.0002067708,0.00008358455,0.00001516034],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00348198,0.00001098871,0.1150072,0.00006583977,0.001405549,0.0002881473,0.000562674,0.005468533,0.8667419,0.0004738918,0.002229827,0.004263506],"study_design_scores_gemma":[0.001901079,0.002227118,0.6834525,0.0002819926,0.0003235229,0.005213362,0.001584171,0.00003208391,0.04259673,0.0006221262,0.2614253,0.0003399872],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906449,0.005704719,0.0001280763,0.0002025939,0.00250577,0.000105034,0.0004523616,0.000009548047,0.0002470399],"genre_scores_gemma":[0.9986208,0.0007058572,0.00007935015,0.00001478136,0.0003490047,4.998903e-7,0.000001814106,0.00001387805,0.0002139841],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8241452,"threshold_uncertainty_score":0.3628983,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01481774505404182,"score_gpt":0.2544794772833303,"score_spread":0.2396617322292885,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}