{"id":"W4392902402","doi":"10.1016/j.jacc.2023.12.034","title":"Genetic Factors Altering Immune Responses in Atrial Fibrillation","year":2024,"lang":"en","type":"article","venue":"Journal of the American College of Cardiology","topic":"IL-33, ST2, and ILC Pathways","field":"Immunology and Microbiology","cited_by":23,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute of Infection and Immunity; Montreal Heart Institute; Université de Montréal","funders":"Canadian Institutes of Health Research; Fédération Française de Cardiologie; Fondation pour la Recherche Médicale; Institut de Cardiologie de Montréal; Servier; Fondation Leducq; Agence Nationale de la Recherche; Institut Servier; European Genomic Institute for Diabetes; Heart and Stroke Foundation of Canada","keywords":"Medicine; Epigenetics; Innate immune system; Atrial fibrillation; Immune system; Immunology; Proinflammatory cytokine; Phenotype; Myeloid; Bioinformatics; Inflammation; Genetics; Gene; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001686201,0.0002812336,0.0001990713,0.0003337681,0.0002509142,0.0003544568,0.0001476369,0.0004332252,0.002629851],"category_scores_gemma":[0.0007103048,0.0001175126,0.000206429,0.0003096628,0.0002075397,0.0001051286,0.0001811257,0.0004175688,0.0001686261],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001091867,"about_ca_system_score_gemma":0.0001758408,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005865549,"about_ca_topic_score_gemma":0.0005592305,"domain_scores_codex":[0.9997609,0.00009592276,0.00002581529,0.00003736221,0.00002599004,0.00005390358],"domain_scores_gemma":[0.999597,0.0001506513,0.0001320023,0.00002334269,0.00001756429,0.00007944091],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0102867,0.000710987,0.3830221,0.0001290583,0.0004361194,0.007383618,0.0004528625,0.001042977,0.5684347,0.001769403,0.001342727,0.02498876],"study_design_scores_gemma":[0.0001887252,0.0007731008,0.9733719,0.00004722782,0.0002622991,0.005135738,0.0003161168,0.002011506,0.01516347,0.0009593801,0.001738943,0.00003161166],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998853,0.0002821792,0.0002177972,0.00009334736,0.00002230809,0.000004142851,0.00009437613,0.000007067754,0.0004258247],"genre_scores_gemma":[0.9993513,0.0001345183,0.0001360766,0.00004142367,0.00002056711,0.000005469194,0.00005517204,0.000004019243,0.0002514012],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002629851,"threshold_uncertainty_score":0.008797705,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01481774505404182,"score_gpt":0.2544794772833303,"score_spread":0.2396617322292885,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}