{"id":"W4392905747","doi":"10.1038/s41467-024-46769-9","title":"Senescence drives immunotherapy resistance by inducing an immunosuppressive tumor microenvironment","year":2024,"lang":"en","type":"article","venue":"Nature Communications","topic":"Immune cells in cancer","field":"Immunology and Microbiology","cited_by":97,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"Government of Canada; CIHR Skin Research Training Centre; Centre hospitalier universitaire Sainte-Justine; Cancer Research Society","keywords":"Immunotherapy; Immune system; Tumor microenvironment; Cancer research; CD8; Cancer immunotherapy; Context (archaeology); T cell; Senescence; Biology; Myeloid; Immunology; Cytotoxic T cell; In vitro; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002770793,0.0002741796,0.0002490834,0.0001122075,0.0006234655,0.00009521595,0.002001358,0.0004501324,0.0003905558],"category_scores_gemma":[0.00004283719,0.000263823,0.0001106343,0.000269759,0.0006916309,0.0003206624,0.0003906316,0.002196772,0.0003640738],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002206647,"about_ca_system_score_gemma":0.0001082546,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000403519,"about_ca_topic_score_gemma":0.00007975603,"domain_scores_codex":[0.9982454,0.0004597616,0.0003733975,0.0004709318,0.00006663783,0.0003838796],"domain_scores_gemma":[0.9965457,0.0003749822,0.0001221972,0.002871884,0.00006156203,0.00002368798],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000405121,0.0001526829,0.0002066736,0.00001915764,0.000180883,0.000003236329,0.001366857,0.000001785632,0.9476125,0.002285416,0.0451824,0.002947943],"study_design_scores_gemma":[0.0003163824,0.00003552154,0.00156333,0.0001994536,0.00003255724,0.00003458058,0.000361463,0.000008457054,0.2211467,0.0001587159,0.7758583,0.0002845278],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.0715507,0.9168694,0.0002481351,0.004208232,0.002217295,0.0005205938,0.0002534939,0.0003787735,0.003753338],"genre_scores_gemma":[0.9792826,0.01065292,0.002032848,0.0007786193,0.00003318962,0.0001430996,0.0006589558,0.00006268405,0.006355058],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.9077319,"threshold_uncertainty_score":0.9999814,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008230556139642775,"score_gpt":0.2738631909457633,"score_spread":0.2656326348061205,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}