{"id":"W4392907173","doi":"10.1016/j.mucimm.2024.03.003","title":"Dendritic cell-mediated responses to secreted Cryptosporidium effectors promote parasite-specific CD8+ T cell responses","year":2024,"lang":"en","type":"article","venue":"Mucosal Immunology","topic":"Parasitic Infections and Diagnostics","field":"Immunology and Microbiology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; European Molecular Biology Organization; Louisiana Academy of Sciences; National Institutes of Health; National Institute of Allergy and Infectious Diseases; Commonwealth of Pennsylvania","keywords":"Effector; Cryptosporidium; Cell mediated immunity; Parasite hosting; Biology; Dendritic cell; Cell; Immunology; Immunity; CD8; Cell biology; T cell; Microbiology; Immune system; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0006172636,0.0005746177,0.0006572594,0.0009495663,0.0004610303,0.0001197168,0.0004587955,0.0008368922,0.001603003],"category_scores_gemma":[0.0008766121,0.0005464469,0.0002454166,0.0009524341,0.0004754495,0.0001582238,0.000215194,0.001021061,0.01866788],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002258513,"about_ca_system_score_gemma":0.0003496216,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000136025,"about_ca_topic_score_gemma":0.00001752842,"domain_scores_codex":[0.9959661,0.001089061,0.0006967502,0.0009350493,0.0000912859,0.001221784],"domain_scores_gemma":[0.9949539,0.003866056,0.0001024286,0.0007801878,0.0001887187,0.0001086899],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00150357,0.000344052,0.002812931,0.00008244559,0.0002325656,0.0005737384,0.000688266,0.0000102265,0.9772995,0.0009032798,0.01462833,0.0009210538],"study_design_scores_gemma":[0.001728324,0.00179957,0.02361967,0.0001368572,0.0001552782,0.000587663,0.0002208567,0.00001972709,0.6233317,0.0001546826,0.3474455,0.0008001367],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9669966,0.0209599,0.0009202196,0.0006123364,0.00692376,0.0008433512,0.0003333581,0.0008634322,0.001547111],"genre_scores_gemma":[0.9915887,0.000608102,0.0002801578,0.0002915336,0.0001420579,0.0002277899,0.0003814239,0.0001000645,0.006380145],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3539678,"threshold_uncertainty_score":0.9996987,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01179368951882423,"score_gpt":0.2590922805243775,"score_spread":0.2472985910055533,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}