{"id":"W4392914804","doi":"10.1080/21645515.2024.2304393","title":"Formulation development of a stable influenza recombinant neuraminidase vaccine candidate","year":2024,"lang":"en","type":"article","venue":"Human Vaccines & Immunotherapeutics","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sanofi (Canada)","funders":"Sanofi","keywords":"RNA; Tetramer; Neuraminidase; Antigenicity; Size-exclusion chromatography; Chemistry; Recombinant DNA; Biochemistry; Biology; Antigen; Enzyme; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003128377,0.0003044466,0.0002361626,0.0001368769,0.0001611908,0.0002921108,0.000290807,0.0003224396,0.0006886117],"category_scores_gemma":[0.0002674451,0.0001448368,0.0002531301,0.0001206888,0.0001270491,0.0002789169,0.0002000644,0.0005265435,0.0004323849],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003439619,"about_ca_system_score_gemma":0.00030213,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005292482,"about_ca_topic_score_gemma":0.0008114437,"domain_scores_codex":[0.9998301,0.00002759217,0.00001473879,0.00003920218,0.00006590498,0.00002231318],"domain_scores_gemma":[0.9999017,0.00001138906,0.0000258269,0.00000803446,0.00003830659,0.00001474691],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002318906,0.00001630979,0.00005662311,0.00003620431,0.000003854956,0.00002769392,0.00001124891,0.0002206059,0.9974583,0.0001012038,0.00004004442,0.00200479],"study_design_scores_gemma":[0.00001274141,0.0005689347,0.0004540193,0.000008187519,0.00001782745,0.0001055488,0.00001679831,0.002303136,0.9922668,0.00004357236,0.004195229,0.000007015021],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9406167,0.002476526,0.05273338,0.0002406537,0.0001061608,0.000402474,0.0004520668,0.0001567991,0.002815155],"genre_scores_gemma":[0.9451656,0.001646844,0.04757638,0.0001200342,0.00002742531,0.0002397076,0.0007640236,0.00007376318,0.004386108],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006886117,"threshold_uncertainty_score":0.002495646,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09857057620514408,"score_gpt":0.3991787651452974,"score_spread":0.3006081889401533,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}