{"id":"W4392921638","doi":"10.1080/10408363.2023.2286606","title":"G protein-coupled receptor (GPCR) gene variants and human genetic disease","year":2024,"lang":"en","type":"review","venue":"Critical Reviews in Clinical Laboratory Sciences","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Hôpital du Sacré-Cœur de Montréal; University of Toronto; Toronto Western Hospital","funders":"H. Lundbeck A/S; Lundbeckfonden; McGill University","keywords":"G protein-coupled receptor; Biology; Receptor; Genetics; 5-HT5A receptor; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004620676,0.0003571727,0.0003873976,0.0006201111,0.0003170384,0.0005280134,0.0002136974,0.0009705696,0.003576012],"category_scores_gemma":[0.001544826,0.0001035567,0.0004798494,0.001637226,0.0005179896,0.0003116891,0.0005401269,0.0006464981,0.0005170987],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003413671,"about_ca_system_score_gemma":0.0003074615,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003496557,"about_ca_topic_score_gemma":0.002201784,"domain_scores_codex":[0.9994062,0.0001429581,0.00005050851,0.0002341612,0.000112466,0.00005367556],"domain_scores_gemma":[0.9996075,0.0001721447,0.0001258984,0.00002414403,0.00003859876,0.00003166122],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001466098,0.0001838057,0.5797045,0.00229104,0.001357087,0.01931714,0.0007610886,0.006959588,0.02551623,0.04226232,0.03814463,0.2820366],"study_design_scores_gemma":[0.0001500615,0.0005026659,0.6573873,0.001391472,0.001492824,0.05751141,0.0006934965,0.007615446,0.005282698,0.05439741,0.2134198,0.0001554144],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.6353526,0.2737472,0.02059448,0.01461849,0.001205224,0.0001119414,0.01096524,0.0004936334,0.04291128],"genre_scores_gemma":[0.9077618,0.07188068,0.008555282,0.002357207,0.0007187874,0.00006477773,0.004334477,0.00007031422,0.004256805],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.003576012,"threshold_uncertainty_score":0.01196295,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1119375626541258,"score_gpt":0.4587674405296113,"score_spread":0.3468298778754855,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}