{"id":"W4392925355","doi":"10.15252/rc.2024320358","title":"Author Reply to Peer Reviews of Metformin protects the heart against chronic intermittent hypoxia through AMPK-dependent phosphorylation of HIF-1α","year":2024,"lang":"en","type":"peer-review","venue":"","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Thrombosis and Atherosclerosis Research Institute","funders":"","keywords":"AMPK; Metformin; Hypoxia (environmental); Phosphorylation; Medicine; Internal medicine; Cardiology; Endocrinology; Chemistry; Biology; Cell biology; Protein kinase A; Insulin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005214151,0.0007444301,0.001295517,0.001432856,0.002278994,0.003184941,0.002021211,0.01308601,0.02135707],"category_scores_gemma":[0.07148108,0.0005510944,0.001087667,0.0006944753,0.001692764,0.002956138,0.001650797,0.0140023,0.01287075],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002140964,"about_ca_system_score_gemma":0.003967077,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003552587,"about_ca_topic_score_gemma":0.005817342,"domain_scores_codex":[0.9946623,0.001087142,0.0007011272,0.0006015945,0.002449732,0.0004980938],"domain_scores_gemma":[0.951758,0.01078864,0.002123987,0.001321504,0.03040284,0.003605087],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004659602,0.000007614757,0.0001590031,0.0001183199,0.00001374016,0.0004374086,0.00005521538,0.00001664923,0.0001313232,0.0004715131,0.9941965,0.00434599],"study_design_scores_gemma":[0.00003940107,0.00002629046,0.0007667395,0.0001742969,0.00002852311,0.0008939703,0.0002055622,0.0001011027,0.0003926466,0.0008830254,0.9964495,0.00003896852],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.000422988,0.003485515,0.000323423,0.6459866,0.3467857,0.00002980215,0.0001936798,0.0001081672,0.002664039],"genre_scores_gemma":[0.01149487,0.01003272,0.0009787873,0.4947802,0.4122508,0.0001254793,0.0003898359,0.0003398724,0.06960763],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.02135707,"threshold_uncertainty_score":0.0714466,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03537223076916503,"score_gpt":0.3276919950106529,"score_spread":0.2923197642414879,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}