{"id":"W4392928088","doi":"10.1021/cen-10208-buscon3","title":"An FDA-approved ALS drug doesn’t work. Now what?","year":2024,"lang":"de","type":"article","venue":"C&EN Global Enterprise","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Drug; Approved drug; Drug approval; Medicine; Business; Pharmacology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.008523928,0.0009709963,0.0008527028,0.0009589845,0.002790292,0.005966776,0.001002323,0.01099311,0.03087416],"category_scores_gemma":[0.02336575,0.0003475734,0.00132241,0.0005963626,0.003922292,0.007544498,0.001646711,0.0130909,0.01747482],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003227547,"about_ca_system_score_gemma":0.004555904,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005926899,"about_ca_topic_score_gemma":0.01701389,"domain_scores_codex":[0.9918277,0.001991894,0.0004872429,0.0008809882,0.004038847,0.0007734094],"domain_scores_gemma":[0.9861125,0.003759311,0.001009666,0.000770086,0.005687881,0.002660583],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001489674,0.0001088159,0.001837087,0.0002565625,0.00006364432,0.0002622552,0.0002247513,0.00004482962,0.001142462,0.01146733,0.870813,0.1136302],"study_design_scores_gemma":[0.0001056282,0.0002489939,0.001073944,0.0004807234,0.00005366789,0.0006700009,0.0004816465,0.00008218829,0.0008384181,0.005920682,0.9899914,0.00005277954],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.001517419,0.01549331,0.0008954292,0.9188418,0.01917845,0.00003879535,0.0002248475,0.0002849229,0.043525],"genre_scores_gemma":[0.02407867,0.01536306,0.002763369,0.8524306,0.006500556,0.00006171286,0.0003406124,0.0002309544,0.09823044],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.03087416,"threshold_uncertainty_score":0.1032844,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01209741902524561,"score_gpt":0.3187184694573523,"score_spread":0.3066210504321067,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}