{"id":"W4392928088","doi":"10.1021/cen-10208-buscon3","title":"An FDA-approved ALS drug doesn’t work. Now what?","year":2024,"lang":"de","type":"article","venue":"C&EN Global Enterprise","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Drug; Approved drug; Drug approval; Medicine; Business; Pharmacology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","scholarly_communication","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.001133647,0.0008549251,0.0009999992,0.0002053427,0.0001877848,0.002068445,0.001218333,0.0005492909,0.003076545],"category_scores_gemma":[0.0002075051,0.0006919007,0.000571103,0.001369304,0.0004422964,0.00153911,0.0007008779,0.00130209,0.01671724],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001926149,"about_ca_system_score_gemma":0.000657722,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003681675,"about_ca_topic_score_gemma":0.00006997187,"domain_scores_codex":[0.9930273,0.0007048009,0.00100877,0.001736532,0.001657029,0.001865617],"domain_scores_gemma":[0.9960452,0.0002306113,0.000124901,0.001734275,0.0002443854,0.001620611],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.003563489,0.003194884,0.04979567,0.00255198,0.004382936,0.006093575,0.008478796,0.0002213447,0.005397406,0.001176037,0.4753056,0.4398383],"study_design_scores_gemma":[0.007512613,0.002211614,0.1353742,0.02341652,0.002876038,0.0001144814,0.002408961,0.01854598,0.0007885022,0.002839518,0.8009471,0.002964451],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.687004,0.2430699,0.001197808,0.04006631,0.01826046,0.003215072,0.0005355946,0.001204409,0.005446437],"genre_scores_gemma":[0.9599538,0.02385841,0.0004032183,0.00262313,0.004518449,0.0001150384,0.0002906344,0.0001662753,0.008071033],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4368738,"threshold_uncertainty_score":0.9995532,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01209741902524561,"score_gpt":0.3187184694573523,"score_spread":0.3066210504321067,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}