{"id":"W4392930588","doi":"10.1016/j.reth.2024.03.002","title":"Effective and stable gene transduction in rhesus macaque iPSCs capable of T-lineage differentiation utilizing the piggyBac system","year":2024,"lang":"en","type":"article","venue":"Regenerative Therapy","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"Primate Research Institute, Kyoto University; Institute for Frontier Life and Medical Sciences, Kyoto University","keywords":"Induced pluripotent stem cell; Transduction (biophysics); Rhesus macaque; Lineage (genetic); Biology; Gene; Macaque; Signal transduction; Neuroscience; Cell biology; Genetics; Computational biology; Embryonic stem cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003621869,0.0001377375,0.0001608186,0.00007470389,0.00007669702,0.00003902611,0.00009071396,0.00009842874,0.000008320707],"category_scores_gemma":[0.000009156357,0.00009521033,0.00005530951,0.0001756561,0.00007714926,0.000009544015,0.00002456481,0.0001228989,0.000001178637],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005185551,"about_ca_system_score_gemma":0.00004882224,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008278569,"about_ca_topic_score_gemma":0.00005577905,"domain_scores_codex":[0.9988168,0.000357966,0.0001839493,0.0003128073,0.0001460906,0.0001824193],"domain_scores_gemma":[0.9996371,0.00004492784,0.00003990086,0.0001844624,0.00006385624,0.00002971095],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000147073,0.00002947374,0.0002624411,0.0001169462,0.0001006636,0.000003154431,0.0003712154,0.0008518393,0.9947191,0.00047219,0.0000471192,0.002878756],"study_design_scores_gemma":[0.0004916259,0.0002085438,0.001226484,0.00006976353,0.000008834801,0.00001161964,0.0002980359,0.009856962,0.9871621,0.00001229628,0.0005578228,0.00009593317],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9818029,0.01296967,0.00411666,0.00009818449,0.0001342559,0.0006311563,0.00002865102,0.000014055,0.0002044921],"genre_scores_gemma":[0.9962311,0.00303311,0.0001008676,0.000008933285,0.0001437535,0.00006849928,0.00006431311,0.00002210002,0.0003272897],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01442826,"threshold_uncertainty_score":0.3882564,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01514746759701274,"score_gpt":0.2669030614045653,"score_spread":0.2517555938075525,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}