{"id":"W4392930588","doi":"10.1016/j.reth.2024.03.002","title":"Effective and stable gene transduction in rhesus macaque iPSCs capable of T-lineage differentiation utilizing the piggyBac system","year":2024,"lang":"en","type":"article","venue":"Regenerative Therapy","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"Primate Research Institute, Kyoto University; Institute for Frontier Life and Medical Sciences, Kyoto University","keywords":"Induced pluripotent stem cell; Transduction (biophysics); Rhesus macaque; Lineage (genetic); Biology; Gene; Macaque; Signal transduction; Neuroscience; Cell biology; Genetics; Computational biology; Embryonic stem cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005172443,0.0004638179,0.0002317719,0.0004261138,0.0002520156,0.0003885449,0.000319987,0.0005793596,0.001184072],"category_scores_gemma":[0.0002868875,0.0001643678,0.0005180261,0.0002028258,0.0003811487,0.0003120495,0.0003525603,0.0006231887,0.0006252805],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002370071,"about_ca_system_score_gemma":0.0003613511,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006649408,"about_ca_topic_score_gemma":0.000582682,"domain_scores_codex":[0.9996768,0.00004781247,0.00005627221,0.00007830891,0.00009808985,0.00004274424],"domain_scores_gemma":[0.999806,0.00003302205,0.00006123335,0.00004175115,0.00003625718,0.00002172583],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001269353,0.00001299368,0.0001293223,0.00003861719,0.00000439887,0.00008123491,0.00002260392,0.00005891485,0.9980667,0.0001077125,0.00003914782,0.001425624],"study_design_scores_gemma":[0.000008061492,0.0001865751,0.001398846,0.00001295411,0.00003638528,0.0005151736,0.00001654814,0.0006812859,0.9920143,0.00005022367,0.005071711,0.000007877767],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9305972,0.004412123,0.05787816,0.0003153339,0.0001270213,0.0004903703,0.001143032,0.0004871494,0.004549592],"genre_scores_gemma":[0.9460945,0.003570393,0.04143196,0.0001681751,0.00003986,0.0004192081,0.002215096,0.0001883034,0.00587259],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001184072,"threshold_uncertainty_score":0.003961146,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01514746759701274,"score_gpt":0.2669030614045653,"score_spread":0.2517555938075525,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}