{"id":"W4392948130","doi":"10.1016/j.breast.2024.103715","title":"Is Oncotype DX testing informative for breast cancers with low ER expression? A retrospective review from a biomarker testing referral center","year":2024,"lang":"en","type":"review","venue":"The Breast","topic":"Breast Cancer Treatment Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"","keywords":"Medicine; Breast cancer; Estrogen receptor; Biomarker; Immunohistochemistry; Oncology; Internal medicine; Single Center; Staining; Cancer; Pathology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002623311,0.0002288608,0.0006198579,0.003301383,0.0003701688,0.0008355635,0.0006439351,0.0005765882,0.0008883795],"category_scores_gemma":[0.0114772,0.00037167,0.0003801821,0.003603519,0.0004197573,0.0004595251,0.0004904666,0.0002277028,0.0003637206],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000680966,"about_ca_system_score_gemma":0.001128301,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003571104,"about_ca_topic_score_gemma":0.00432684,"domain_scores_codex":[0.9958757,0.00105916,0.001303526,0.0006295486,0.0009132041,0.0002189177],"domain_scores_gemma":[0.9787359,0.006727959,0.0100798,0.0007606263,0.00318108,0.0005146168],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001847166,0.00003523321,0.9734049,0.001453427,0.0001518904,0.004039049,0.0004397635,0.00004055615,0.00162971,0.0000373773,0.001013313,0.01757003],"study_design_scores_gemma":[0.00002346002,0.0002464826,0.9678282,0.001196803,0.0004686039,0.02189942,0.001348588,0.0001077144,0.001040484,0.00001186531,0.005810915,0.00001754683],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.940001,0.05548247,0.000472123,0.000388579,0.00005584702,0.000109971,0.001530681,0.00002240714,0.001937025],"genre_scores_gemma":[0.9824589,0.01542047,0.0003412859,0.000412143,0.000059627,0.00005494757,0.001091606,0.000009699923,0.0001512071],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003571104,"threshold_uncertainty_score":0.01387352,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05407487999830693,"score_gpt":0.3393136598317154,"score_spread":0.2852387798334085,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}