{"id":"W4392948130","doi":"10.1016/j.breast.2024.103715","title":"Is Oncotype DX testing informative for breast cancers with low ER expression? A retrospective review from a biomarker testing referral center","year":2024,"lang":"en","type":"review","venue":"The Breast","topic":"Breast Cancer Treatment Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"","keywords":"Medicine; Breast cancer; Estrogen receptor; Biomarker; Immunohistochemistry; Oncology; Internal medicine; Single Center; Staining; Cancer; Pathology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002206177,0.0008446751,0.001327345,0.0000622728,0.0002748319,0.00007700619,0.0004781805,0.0002335313,0.00003528674],"category_scores_gemma":[0.0001163732,0.0004503372,0.000425691,0.0005113566,0.0002170649,0.00001660448,0.0004364514,0.0003599619,0.00004857912],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004474861,"about_ca_system_score_gemma":0.0007111792,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003547802,"about_ca_topic_score_gemma":0.00009457861,"domain_scores_codex":[0.9976161,0.0001242549,0.0005968282,0.0008477726,0.0002853995,0.0005296246],"domain_scores_gemma":[0.9979195,0.0001558798,0.0006066427,0.0007865744,0.0004217098,0.0001096733],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003417175,0.00009521195,0.0006513379,0.02260437,0.003288797,0.00001607314,0.0003151784,7.243404e-7,0.00004026915,0.000004187756,0.03228744,0.9403547],"study_design_scores_gemma":[0.001818343,0.000410888,0.003183481,0.3900549,0.008597934,0.003558625,0.000215331,0.00002341143,0.00004603971,0.00007119834,0.590088,0.001931897],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00003943629,0.9858256,0.00003585572,0.0002971027,0.0002187283,0.00181583,0.009983324,0.00006094372,0.001723206],"genre_scores_gemma":[0.0009208249,0.9934824,0.0009763828,0.0006010975,0.000835964,0.001502906,0.001227599,0.0001788352,0.0002739959],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9384228,"threshold_uncertainty_score":0.9997948,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05407487999830693,"score_gpt":0.3393136598317154,"score_spread":0.2852387798334085,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}