{"id":"W4392952007","doi":"10.1128/mbio.00419-24","title":"Structural insight into <i>Escherichia coli</i> CsgA amyloid fibril assembly","year":2024,"lang":"en","type":"article","venue":"mBio","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; University of Minnesota","keywords":"Escherichia coli; Amyloid fibril; Amyloid (mycology); Chemistry; Fibril; Escherichia coli Proteins; Biochemistry; Computational biology; Biophysics; Biology; Amyloid β; Medicine; Disease; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008269959,0.0002319114,0.0000931557,0.0001829464,0.0001836311,0.0002560216,0.0001438773,0.0003248215,0.0010333],"category_scores_gemma":[0.0001092865,0.0001232653,0.000228154,0.0001016228,0.0001678535,0.0002483302,0.0001461579,0.0004502656,0.0003825044],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002094237,"about_ca_system_score_gemma":0.0001553422,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00124638,"about_ca_topic_score_gemma":0.0009870685,"domain_scores_codex":[0.9999648,0.000003991597,0.000002043614,0.000008545092,0.000009245087,0.00001125605],"domain_scores_gemma":[0.9999195,0.00001345212,0.00002070681,0.000007218745,0.00002257874,0.00001651343],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005257281,0.00001725486,0.001041691,0.00005342302,0.00000586442,0.0002377278,0.000048904,0.0006240265,0.9959419,0.0003380234,0.0002172985,0.001421307],"study_design_scores_gemma":[0.00001278154,0.000220528,0.02307487,0.00005863506,0.00003304654,0.001471346,0.00030251,0.02708129,0.9372628,0.001290276,0.009160466,0.00003149575],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9758149,0.001297434,0.01773088,0.000306657,0.00004027709,0.00001883566,0.0003974099,0.0003103417,0.004083266],"genre_scores_gemma":[0.9897673,0.0005111404,0.00815895,0.0001818813,0.00001170562,0.000008474403,0.0004248357,0.00003608606,0.0008998268],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00124638,"threshold_uncertainty_score":0.003456771,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02250031339718879,"score_gpt":0.3080355239371158,"score_spread":0.285535210539927,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}