{"id":"W4392953623","doi":"10.1093/pnasnexus/pgae084","title":"Natural soda lakes provide compatible conditions for RNA and membrane function that could have enabled the origin of life","year":2024,"lang":"en","type":"article","venue":"PNAS Nexus","topic":"Origins and Evolution of Life","field":"Physics and Astronomy","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Science Foundation Graduate Research Fellowship Program; National Science Foundation of Sri Lanka; Simons Foundation; National Aeronautics and Space Administration; National Science Foundation","keywords":"RNA; Membrane; Divalent; Chemistry; Vesicle; Phosphate; Biochemistry; Environmental chemistry; Biophysics; Biology; Organic chemistry; Gene","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001438068,0.0002997747,0.0003401915,0.0002141763,0.001065709,0.0006597221,0.0003852862,0.0003880729,0.001374426],"category_scores_gemma":[0.0003483219,0.000288227,0.0001798669,0.0001778996,0.0005166174,0.0005668786,0.0006297706,0.0003329723,0.0002926348],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001145093,"about_ca_system_score_gemma":0.001036346,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01123267,"about_ca_topic_score_gemma":0.04778558,"domain_scores_codex":[0.9998548,0.00001718693,0.00001196492,0.0000481886,0.00002858191,0.00003923078],"domain_scores_gemma":[0.9997618,0.00002817202,0.00006680152,0.00001865167,0.00007122047,0.00005332071],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000122717,0.00003271822,0.01089534,0.00008528854,0.00001050124,0.0001162409,0.0001720935,0.00009946499,0.9863225,0.0004052828,0.0001580021,0.001579819],"study_design_scores_gemma":[0.000151375,0.0008084727,0.2344642,0.00006980529,0.00007586533,0.0007655667,0.002423845,0.006145509,0.7268613,0.001417187,0.02672881,0.00008798519],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995616,0.0001118531,0.001947903,0.0001305349,0.00001442653,0.00005828993,0.0004346295,0.00005519469,0.00163118],"genre_scores_gemma":[0.9933382,0.00005704516,0.00487436,0.00007415285,0.000004384126,0.00007374382,0.0003720167,0.00002176687,0.001184254],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01123267,"threshold_uncertainty_score":0.02233458,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02480229013214118,"score_gpt":0.2757331205710362,"score_spread":0.250930830438895,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}