{"id":"W4392954953","doi":"10.1021/acs.biochem.3c00724","title":"Cryo-EM of the Nucleosome Core Particle Bound to Ran-RCC1 Reveals a Dynamic Complex","year":2024,"lang":"en","type":"article","venue":"Biochemistry","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Ran; Nucleosome; Chromatin; Guanine nucleotide exchange factor; Cell biology; GTP'; Ras superfamily; Nuclear transport; Chemistry; GTPase; Biology; Biophysics; Biochemistry; Cell nucleus; DNA; Cytoplasm","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001522878,0.0003251233,0.0001708498,0.0001899341,0.0005147409,0.0002476226,0.0004177536,0.0006115612,0.001366622],"category_scores_gemma":[0.0001365914,0.0002601768,0.0002303604,0.0001879067,0.0003429998,0.0003592563,0.0002915337,0.0008923311,0.0003639901],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003836859,"about_ca_system_score_gemma":0.0002187558,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002349832,"about_ca_topic_score_gemma":0.0029428,"domain_scores_codex":[0.999947,0.000004318791,0.000002648124,0.00001373958,0.00001595161,0.00001638668],"domain_scores_gemma":[0.9999141,0.00002206176,0.00001378774,0.000009834896,0.00001825476,0.00002193371],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002262565,0.00009931671,0.003048562,0.0001546259,0.00006154841,0.001132231,0.0002047888,0.002055091,0.9875543,0.001163993,0.001015609,0.003283623],"study_design_scores_gemma":[0.00009190662,0.0006307178,0.1530433,0.0001725996,0.0002195093,0.005707094,0.0009416926,0.07587303,0.7343982,0.001054322,0.02778221,0.00008544479],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.973798,0.002906702,0.01450737,0.0006107634,0.0001209302,0.00003324223,0.0006178727,0.0001682899,0.007236641],"genre_scores_gemma":[0.9782808,0.001619687,0.01426299,0.0003515404,0.00003758237,0.00004372893,0.001688126,0.00008987366,0.003625712],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002349832,"threshold_uncertainty_score":0.004672348,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01204111516432521,"score_gpt":0.2579472856012063,"score_spread":0.2459061704368811,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}