{"id":"W4392956053","doi":"10.1038/s41589-024-01578-5","title":"Design of amyloidogenic peptide traps","year":2024,"lang":"en","type":"article","venue":"Nature Chemical Biology","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"National Institute of General Medical Sciences","keywords":"Peptide; Amyloid (mycology); Transthyretin; Chemistry; In vitro; Fibril; Biochemistry; Peptide sequence; Biophysics; Cell biology; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002734053,0.0003299302,0.0002555185,0.0002312344,0.0002017465,0.0004099032,0.0006242959,0.0004396327,0.0009963253],"category_scores_gemma":[0.0002290238,0.0002399372,0.0001812376,0.0001092149,0.0001913109,0.0003149906,0.0004162587,0.0004814303,0.0004480494],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003062551,"about_ca_system_score_gemma":0.0002218134,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000109212,"about_ca_topic_score_gemma":0.0002000299,"domain_scores_codex":[0.9998336,0.00002520704,0.00001196981,0.00003725129,0.00005011236,0.00004196115],"domain_scores_gemma":[0.9998446,0.00002307953,0.00004303699,0.00001092992,0.00003409425,0.00004424461],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001503846,0.0002002654,0.0003423971,0.0001874177,0.00002548914,0.0001796799,0.00005640863,0.004464075,0.9793227,0.004148679,0.0005108491,0.01041164],"study_design_scores_gemma":[0.0001605892,0.0012373,0.0004231418,0.00002363273,0.00002469868,0.0002862848,0.00004204453,0.02413161,0.9594994,0.001096799,0.01304486,0.00002964706],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8436049,0.003354503,0.1428204,0.0003595827,0.0002167719,0.0007314559,0.0004830973,0.0006603,0.007768899],"genre_scores_gemma":[0.94562,0.0007210106,0.0497884,0.0001789957,0.00001706791,0.0004283673,0.0002251387,0.00003099904,0.002990049],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009963253,"threshold_uncertainty_score":0.003333032,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02468943759659342,"score_gpt":0.3386126049628771,"score_spread":0.3139231673662837,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}