{"id":"W4392959526","doi":"10.1002/alz.13789","title":"Glymphatic system dysfunction predicts amyloid deposition, neurodegeneration, and clinical progression in Alzheimer's disease","year":2024,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Cerebrospinal fluid and hydrocephalus","field":"Neuroscience","cited_by":215,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; Canadian Institutes of Health Research; National Institutes of Health; H. Lundbeck A/S; Shanghai Rising-Star Program; Servier; Huashan Hospital; National Natural Science Foundation of China; Eisai; Genentech; IXICO; Northern California Institute for Research and Education; Fudan University; BioClinica; Biogen; Pfizer; Novartis Pharmaceuticals Corporation; University of Southern California; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; Alzheimer's Disease Neuroimaging Initiative; Meso Scale Diagnostics; Alzheimer's Association","keywords":"Cognitive decline; Dementia; Atrophy; Neurodegeneration; Pittsburgh compound B; Medicine; Amyloid (mycology); Alzheimer's disease; Pathology; Positron emission tomography; Glymphatic system; Neuroimaging; Cerebrospinal fluid; Psychology; Internal medicine; Neuroscience; Disease","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004464511,0.0005974202,0.0002657834,0.0009903691,0.0002601802,0.0005001797,0.0001615574,0.0002934763,0.00112201],"category_scores_gemma":[0.0008806494,0.0001278873,0.0002504756,0.0004349183,0.000228973,0.0003096496,0.0004610324,0.00029721,0.000194587],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002265979,"about_ca_system_score_gemma":0.0001820954,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001501684,"about_ca_topic_score_gemma":0.002189405,"domain_scores_codex":[0.9999124,0.00002093532,0.00001389949,0.00002280463,0.00001757502,0.00001240913],"domain_scores_gemma":[0.9994562,0.00004409956,0.0002749683,0.00003017162,0.00007513373,0.000119301],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009931723,0.00005063611,0.9892991,0.00005846724,0.0001820186,0.0001608964,0.00007533441,0.0001531098,0.004151502,0.0000352137,0.0001569273,0.0046836],"study_design_scores_gemma":[0.000008843083,0.0001373506,0.9983934,0.00001520368,0.00004215835,0.000345663,0.00005449524,0.0003408997,0.0004207858,0.0001204672,0.0001165708,0.000004241579],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983948,0.0007054841,0.000118822,0.00003204427,0.000004229914,0.000009063231,0.0002328479,0.000006038657,0.0004965121],"genre_scores_gemma":[0.9992979,0.0001907903,0.0001892975,0.000009889708,0.000004256854,0.000004565735,0.000202074,0.000001395986,0.000099815],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001501684,"threshold_uncertainty_score":0.003753483,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02972718428174452,"score_gpt":0.3015262132897844,"score_spread":0.2717990290080399,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}