{"id":"W4392959526","doi":"10.1002/alz.13789","title":"Glymphatic system dysfunction predicts amyloid deposition, neurodegeneration, and clinical progression in Alzheimer's disease","year":2024,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Cerebrospinal fluid and hydrocephalus","field":"Neuroscience","cited_by":215,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; Canadian Institutes of Health Research; National Institutes of Health; H. Lundbeck A/S; Shanghai Rising-Star Program; Servier; Huashan Hospital; National Natural Science Foundation of China; Eisai; Genentech; IXICO; Northern California Institute for Research and Education; Fudan University; BioClinica; Biogen; Pfizer; Novartis Pharmaceuticals Corporation; University of Southern California; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; Alzheimer's Disease Neuroimaging Initiative; Meso Scale Diagnostics; Alzheimer's Association","keywords":"Cognitive decline; Dementia; Atrophy; Neurodegeneration; Pittsburgh compound B; Medicine; Amyloid (mycology); Alzheimer's disease; Pathology; Positron emission tomography; Glymphatic system; Neuroimaging; Cerebrospinal fluid; Psychology; Internal medicine; Neuroscience; Disease","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003364637,0.000249363,0.0002179427,0.0001703731,0.0002428142,0.0003217266,0.0001604529,0.00008928853,0.00003971234],"category_scores_gemma":[0.00006997929,0.0002248003,0.00009426798,0.0004034092,0.0001276885,0.0005759504,0.000117401,0.0001695393,0.0001258676],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001442343,"about_ca_system_score_gemma":0.0001107497,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002948641,"about_ca_topic_score_gemma":0.00002159704,"domain_scores_codex":[0.9974081,0.0002920377,0.0006547936,0.00087841,0.0004244047,0.0003422716],"domain_scores_gemma":[0.9991932,0.0001195887,0.00008373756,0.0002868494,0.00003835238,0.0002782655],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.001552185,0.002215088,0.134091,0.0005620407,0.004905427,0.002588083,0.0008830857,0.0007530303,0.1013796,0.04226762,0.0119361,0.6968668],"study_design_scores_gemma":[0.00446417,0.001585164,0.2190795,0.001830122,0.03897309,0.0004727103,0.0001003996,0.5770797,0.1456933,0.0008954609,0.007918657,0.001907679],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7717895,0.2185286,0.001375736,0.0009466768,0.004270475,0.001508545,0.0000376072,0.0007670507,0.000775807],"genre_scores_gemma":[0.9985194,0.0004243194,0.0001359435,0.000366337,0.0003757337,0.00009816453,0.00003128952,0.00004311584,0.00000567789],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6949591,"threshold_uncertainty_score":0.9167089,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02972718428174452,"score_gpt":0.3015262132897844,"score_spread":0.2717990290080399,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}