{"id":"W4392967953","doi":"10.1101/2024.03.18.584896","title":"Gene editing of <i>CD3 epsilon</i> gene to redirect regulatory T cells for adoptive T cell transfer","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network","funders":"","keywords":"Adoptive cell transfer; Gene; Gene transfer; T cell; Genome editing; CD3; Biology; Cell biology; Genetics; Immune system; CD8; Genome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000164717,0.0004275762,0.0001669672,0.0001612253,0.000110921,0.000305806,0.0002928597,0.0003542343,0.001718458],"category_scores_gemma":[0.0001002083,0.0001177282,0.0002689335,0.0001067363,0.0002532819,0.0001301762,0.0001903249,0.0006650381,0.0005257868],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002474053,"about_ca_system_score_gemma":0.0001536545,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004480638,"about_ca_topic_score_gemma":0.0004294649,"domain_scores_codex":[0.9998424,0.00001992234,0.00001572183,0.00003943153,0.00004176928,0.00004070922],"domain_scores_gemma":[0.999884,0.00001688376,0.00004586012,0.00001794036,0.00001336719,0.00002189556],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000252214,0.00001228773,0.00003935747,0.0000190867,0.000002878909,0.00003041039,0.000005477952,0.00008268902,0.9986919,0.0001329118,0.00006168036,0.0008960978],"study_design_scores_gemma":[0.000007343789,0.00007100126,0.0002815539,0.000002318083,0.000006595404,0.000116619,0.000003829878,0.0007884652,0.9963197,0.00002789275,0.002371063,0.000003571814],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9246722,0.0007222113,0.06711283,0.0001953883,0.000228862,0.0002223744,0.0008845871,0.001114756,0.004846787],"genre_scores_gemma":[0.97812,0.0002555695,0.01672247,0.00009221822,0.00001546523,0.00008866772,0.000408363,0.0001307452,0.004166586],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001718458,"threshold_uncertainty_score":0.005748808,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02090986418884194,"score_gpt":0.2559609035531854,"score_spread":0.2350510393643435,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}