{"id":"W4392968969","doi":"10.1101/2024.03.13.24304161","title":"Genome-wide analyses identify 30 loci associated with obsessive-compulsive disorder","year":2024,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Obsessive-Compulsive Spectrum Disorders","field":"Psychology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; BC Mental Health & Substance Use Services; Health Sciences Centre; Sunnybrook Health Science Centre; McMaster University; BC Children's Hospital; Dalhousie University; University of Toronto; Centre for Addiction and Mental Health; University of British Columbia; Hospital for Sick Children","funders":"National Center for Advancing Translational Sciences; National Center for Research Resources; National Institute of Mental Health; Faculty of Medicine and Health, University of Sydney; Instituto de Salud Carlos III; National Health and Medical Research Council; NIHR Maudsley Biomedical Research Centre; Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai; Cereal Partners Worldwide; Department of Psychiatry, University of Toronto; Stanley Center for Psychiatric Research, Broad Institute; SUNY Downstate Medical Center; University of North Carolina at Chapel Hill; National Institutes of Health; National Institute on Aging; Fundació Institut de Recerca Hospital Universitari Vall d’Hebron; Universitat Autònoma de Barcelona; European College of Neuropsychopharmacology; Centro de Investigación Biomédica en Red de Salud Mental; Norwegian Institute of Public Health; Humboldt-Universität zu Berlin; Campbell Family Mental Health Research Institute; Helse Midt-Norge; Novo Nordisk; Bundesministerium für Bildung und Forschung; Universiteit van Amsterdam; European Commission; European Regional Development Fund; King's College London; Department of Health and Social Care; Ontario Council on Graduate Studies, Council of Ontario Universities; Ministero dell’Istruzione, dell’Università e della Ricerca; Norges Forskningsråd; QIMR Berghofer Medical Research Institute; Amsterdam University Medical Centers; Universidade de Santiago de Compostela; Helse- og Omsorgsdepartementet; National Center for PTSD, U.S. Department of Veterans Affairs; Deutsche Forschungsgemeinschaft; Norges Teknisk-Naturvitenskapelige Universitet; Stichting Volksbond Rotterdam; NIH Clinical Center; Trond Mohn stiftelse; Fundación Instituto de Investigación Sanitaria de Santiago de Compostela; McMaster University; Ministerio de Ciencia, Innovación y Universidades; Vetenskapsrådet; Roy J. and Lucille A. Carver College of Medicine, University of Iowa; Instituto de Investigación Sanitaria de Santiago de Compostela; Georgia Clinical and Translational Science Alliance; Stockholms Läns Landsting; Aarhus Universitet; Vanderbilt University Medical Center; Aarhus Universitetshospital; Beatrice and Samuel A. Seaver Foundation; Medical Research Council; Tartu Ülikool; Fundació la Marató de TV3; Johns Hopkins University; FP7 Health; University of Toronto; Office of Research and Development; Karolinska Institutet; Yale University; U.S. Department of Veterans Affairs; Agència de Gestió d'Ajuts Universitaris i de Recerca; National Institute for Health and Care Research; Lundbeckfonden; Center for Innovative Medicine; State University of New York; H. Lundbeck A/S; Hospital for Sick Children; Forskningsrådet om Hälsa, Arbetsliv och Välfärd; Broad Institute; AFA Försäkring; McLean Hospital; Vanderbilt University; Ministero della Salute; International OCD Foundation; Massachusetts General Hospital","keywords":"Genome-wide association study; Association (psychology); Obsessive compulsive; Genetics; Biology; Psychology; Psychiatry; Single-nucleotide polymorphism; Genotype; Gene; Psychotherapist","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005940265,0.0005109349,0.0004123857,0.0009645871,0.0003430425,0.0007616469,0.00035546,0.0004626704,0.003220093],"category_scores_gemma":[0.0009996307,0.0002439349,0.001121957,0.001444098,0.0002570106,0.0001048473,0.0005058424,0.0004719057,0.0002614467],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001659794,"about_ca_system_score_gemma":0.0002172546,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004624739,"about_ca_topic_score_gemma":0.006243901,"domain_scores_codex":[0.9996741,0.00009081377,0.0000305849,0.0001149861,0.00004502494,0.00004441952],"domain_scores_gemma":[0.9993718,0.0002698748,0.0001849139,0.00004899156,0.00003914406,0.0000852286],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002171091,0.0001312148,0.9520618,0.0002326623,0.007384848,0.001059834,0.0001358318,0.0007727311,0.01519604,0.0002558914,0.002767614,0.01783055],"study_design_scores_gemma":[0.0001989843,0.00009313699,0.9941074,0.00003912464,0.001994082,0.0005156497,0.0001185934,0.0005808952,0.0007148335,0.000314018,0.001312504,0.00001075698],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906123,0.004392804,0.0007399726,0.0004437008,0.00004235864,0.00001194725,0.002832606,0.00006494301,0.0008593486],"genre_scores_gemma":[0.9955243,0.0009449901,0.0006141806,0.0001769228,0.00003461439,0.00001326759,0.002156436,0.00001397605,0.000521316],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004624739,"threshold_uncertainty_score":0.01077223,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03175854508331744,"score_gpt":0.3443827881360293,"score_spread":0.3126242430527119,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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