{"id":"W4392968969","doi":"10.1101/2024.03.13.24304161","title":"Genome-wide analyses identify 30 loci associated with obsessive-compulsive disorder","year":2024,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Obsessive-Compulsive Spectrum Disorders","field":"Psychology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; BC Mental Health & Substance Use Services; Health Sciences Centre; Sunnybrook Health Science Centre; McMaster University; BC Children's Hospital; Dalhousie University; University of Toronto; Centre for Addiction and Mental Health; University of British Columbia; Hospital for Sick Children","funders":"National Center for Advancing Translational Sciences; National Center for Research Resources; National Institute of Mental Health; Faculty of Medicine and Health, University of Sydney; Instituto de Salud Carlos III; National Health and Medical Research Council; NIHR Maudsley Biomedical Research Centre; Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai; Cereal Partners Worldwide; Department of Psychiatry, University of Toronto; Stanley Center for Psychiatric Research, Broad Institute; SUNY Downstate Medical Center; University of North Carolina at Chapel Hill; National Institutes of Health; National Institute on Aging; Fundació Institut de Recerca Hospital Universitari Vall d’Hebron; Universitat Autònoma de Barcelona; European College of Neuropsychopharmacology; Centro de Investigación Biomédica en Red de Salud Mental; Norwegian Institute of Public Health; Humboldt-Universität zu Berlin; Campbell Family Mental Health Research Institute; Helse Midt-Norge; Novo Nordisk; Bundesministerium für Bildung und Forschung; Universiteit van Amsterdam; European Commission; European Regional Development Fund; King's College London; Department of Health and Social Care; Ontario Council on Graduate Studies, Council of Ontario Universities; Ministero dell’Istruzione, dell’Università e della Ricerca; Norges Forskningsråd; QIMR Berghofer Medical Research Institute; Amsterdam University Medical Centers; Universidade de Santiago de Compostela; Helse- og Omsorgsdepartementet; National Center for PTSD, U.S. Department of Veterans Affairs; Deutsche Forschungsgemeinschaft; Norges Teknisk-Naturvitenskapelige Universitet; Stichting Volksbond Rotterdam; NIH Clinical Center; Trond Mohn stiftelse; Fundación Instituto de Investigación Sanitaria de Santiago de Compostela; McMaster University; Ministerio de Ciencia, Innovación y Universidades; Vetenskapsrådet; Roy J. and Lucille A. Carver College of Medicine, University of Iowa; Instituto de Investigación Sanitaria de Santiago de Compostela; Georgia Clinical and Translational Science Alliance; Stockholms Läns Landsting; Aarhus Universitet; Vanderbilt University Medical Center; Aarhus Universitetshospital; Beatrice and Samuel A. Seaver Foundation; Medical Research Council; Tartu Ülikool; Fundació la Marató de TV3; Johns Hopkins University; FP7 Health; University of Toronto; Office of Research and Development; Karolinska Institutet; Yale University; U.S. Department of Veterans Affairs; Agència de Gestió d'Ajuts Universitaris i de Recerca; National Institute for Health and Care Research; Lundbeckfonden; Center for Innovative Medicine; State University of New York; H. Lundbeck A/S; Hospital for Sick Children; Forskningsrådet om Hälsa, Arbetsliv och Välfärd; Broad Institute; AFA Försäkring; McLean Hospital; Vanderbilt University; Ministero della Salute; International OCD Foundation; Massachusetts General Hospital","keywords":"Genome-wide association study; Association (psychology); Obsessive compulsive; Genetics; Biology; Psychology; Psychiatry; Single-nucleotide polymorphism; Genotype; Gene; Psychotherapist","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["metaepi_narrow","insufficient_payload"],"category_scores_codex":[0.0005677029,0.001688562,0.002089546,0.001100252,0.0003311757,0.0005393014,0.002054762,0.001158944,0.008975641],"category_scores_gemma":[0.0006274607,0.001476412,0.0009558107,0.00157242,0.0007744571,0.0001261768,0.002130768,0.003738324,0.005364493],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005622933,"about_ca_system_score_gemma":0.0004613827,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009381996,"about_ca_topic_score_gemma":0.0009203131,"domain_scores_codex":[0.9915746,0.001047481,0.001355687,0.003126202,0.001216574,0.001679486],"domain_scores_gemma":[0.9943929,0.0008500277,0.001340032,0.002411951,0.0005757161,0.0004293362],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002650988,0.001583266,0.9534176,0.0006701127,0.01521488,0.003910646,0.0100843,0.004574456,0.0004280287,0.001105726,0.007036678,0.001709228],"study_design_scores_gemma":[0.001822592,0.0002283058,0.976022,0.0006410457,0.001848058,0.00002059539,0.002652388,0.0001969942,0.00008632789,0.01202043,0.002487724,0.001973543],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9514175,0.01319845,0.001305411,0.001438945,0.003847422,0.001645127,0.0004404942,0.0009947214,0.02571195],"genre_scores_gemma":[0.9892004,0.000160324,0.0001491848,0.0004808096,0.0004843879,0.0005774176,0.001379105,0.0005071357,0.007061239],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03778292,"threshold_uncertainty_score":0.9995861,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03175854508331744,"score_gpt":0.3443827881360293,"score_spread":0.3126242430527119,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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