{"id":"W4392968990","doi":"10.1101/2024.03.12.584665","title":"Inactive Parp2 causes Tp53-dependent lethal anemia by blocking replication-associated nick ligation in erythroblasts","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Columbia College","funders":"National Institutes of Health; St. Jude Children's Research Hospital","keywords":"DNA damage; Cancer research; Biology; PARP1; Cell biology; Poly ADP ribose polymerase; DNA; Polymerase; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[{"model":"gemma","categories":[],"domain":null,"study_design":"bench_or_experimental","genre":"empirical","about_ca_system":false,"about_ca_topic":false,"confidence":"high","status":"direct model label, unvalidated"},{"model":"gpt","categories":[],"domain":null,"study_design":"bench_or_experimental","genre":"empirical","about_ca_system":false,"about_ca_topic":false,"confidence":"high","status":"direct model label, unvalidated"}],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002045611,0.0003346708,0.0002171507,0.0001781539,0.0001351923,0.000303457,0.0003264965,0.0003250179,0.00298823],"category_scores_gemma":[0.0001078399,0.0001550224,0.0002589458,0.0001004897,0.0002085124,0.0001758066,0.0001698549,0.0007860946,0.000623585],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001973765,"about_ca_system_score_gemma":0.0001424313,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000300543,"about_ca_topic_score_gemma":0.0002699613,"domain_scores_codex":[0.9998085,0.00003317576,0.00003148815,0.00004891011,0.00004102011,0.00003692833],"domain_scores_gemma":[0.9998478,0.00002247222,0.00004805206,0.00002537789,0.00001049626,0.00004583936],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001797329,0.0000576052,0.0001853145,0.00003705891,0.000009735276,0.00006394833,0.000008018787,0.00008484576,0.9981148,0.0002068834,0.0001244379,0.0009275275],"study_design_scores_gemma":[0.00002396881,0.0003535333,0.00161373,0.000004300595,0.0000146137,0.0003306068,0.00001322663,0.000863487,0.9947694,0.00005244595,0.001957917,0.000002861376],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9854811,0.002274282,0.007533377,0.000258614,0.000101507,0.00006057681,0.001152507,0.0003152571,0.002822716],"genre_scores_gemma":[0.9935809,0.0005708021,0.001534742,0.00007300692,0.00001343738,0.00004294156,0.0008152036,0.00003751857,0.003331418],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00298823,"threshold_uncertainty_score":0.009996593,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01698238781180989,"score_gpt":0.2725188780945896,"score_spread":0.2555364902827797,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}