{"id":"W4392977246","doi":"10.1056/nejmoa2305488","title":"Ribociclib plus Endocrine Therapy in Early Breast Cancer","year":2024,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":357,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"Novartis Pharmaceuticals Corporation","keywords":"Medicine; Letrozole; Breast cancer; Anastrozole; Internal medicine; Goserelin; Oncology; Aromatase inhibitor; Cancer; Interim analysis; Clinical endpoint; Tamoxifen; Gynecology; Randomized controlled trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0004593209,0.0002072587,0.0006353599,0.0004190553,0.00002089633,0.000014143,0.0001303299,0.00005150373,0.001023418],"category_scores_gemma":[0.00005379739,0.0001245163,0.00009633062,0.0004530209,0.0001223598,0.0002105506,0.00001397359,0.0006702103,0.000007722351],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000281453,"about_ca_system_score_gemma":0.0005545359,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007190362,"about_ca_topic_score_gemma":0.00008353357,"domain_scores_codex":[0.9983377,0.00005474014,0.0005807334,0.0001802148,0.000549514,0.0002971189],"domain_scores_gemma":[0.9990512,0.0001696839,0.0001423911,0.0001609076,0.0001673326,0.0003085608],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.004659812,0.00005021739,0.01902098,0.00008612498,0.0002732495,0.00247529,0.003553689,0.00008621799,0.009701113,0.0001857143,0.002066855,0.9578407],"study_design_scores_gemma":[0.1866103,0.003976997,0.2494176,0.007831814,0.000292389,0.03151877,0.0005243207,0.000235814,0.001708284,0.003476265,0.5140362,0.0003711733],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8568761,0.06951894,0.0006986659,0.06998052,0.001938068,0.0002335977,0.00001089128,0.00005235921,0.0006908451],"genre_scores_gemma":[0.9798521,0.006856561,0.0003075865,0.001140202,0.01056708,0.000004874812,0.000002330391,0.00004434096,0.001224955],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9574696,"threshold_uncertainty_score":0.9998898,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02150004405986991,"score_gpt":0.3288692249692114,"score_spread":0.3073691809093416,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}