{"id":"W4392977246","doi":"10.1056/nejmoa2305488","title":"Ribociclib plus Endocrine Therapy in Early Breast Cancer","year":2024,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":357,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"Novartis Pharmaceuticals Corporation","keywords":"Medicine; Letrozole; Breast cancer; Anastrozole; Internal medicine; Goserelin; Oncology; Aromatase inhibitor; Cancer; Interim analysis; Clinical endpoint; Tamoxifen; Gynecology; Randomized controlled trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001601076,0.0003999202,0.001042061,0.0003267331,0.0001353755,0.000428616,0.0003896107,0.0004729436,0.00287874],"category_scores_gemma":[0.001182127,0.0001178709,0.0006520424,0.0003959213,0.0003547129,0.0002912767,0.0002565997,0.001266832,0.0003881087],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004448313,"about_ca_system_score_gemma":0.0008641059,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003271034,"about_ca_topic_score_gemma":0.001430388,"domain_scores_codex":[0.9995259,0.0002785395,0.00004438136,0.00004915826,0.00004807573,0.00005406475],"domain_scores_gemma":[0.9994268,0.0002291239,0.0001160371,0.00004011377,0.00003244917,0.0001554582],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7246861,0.01114245,0.003772848,0.002740546,0.001031399,0.0002135568,0.00009388164,0.002097557,0.01335489,0.0004653939,0.002142166,0.2382591],"study_design_scores_gemma":[0.6005184,0.368201,0.01022887,0.0003834208,0.001491099,0.0006628846,0.00003877348,0.001150706,0.004618605,0.0007118689,0.01196841,0.00002604271],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9427202,0.04523921,0.001269328,0.0009401841,0.0003947537,0.002323473,0.0008071925,0.00009741322,0.006208101],"genre_scores_gemma":[0.9839516,0.009402379,0.001885163,0.001036402,0.0002404398,0.001330736,0.0006616688,0.00001510894,0.001476463],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00287874,"threshold_uncertainty_score":0.009630322,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02150004405986991,"score_gpt":0.3288692249692114,"score_spread":0.3073691809093416,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}