{"id":"W4392980871","doi":"10.1016/j.bioorg.2024.107299","title":"Design, synthesis and biological evaluation of new 2,6-difluorinated phenyl 4-(2-oxoimidazolidin-1-yl)benzenesulfonates as new antimicrotubule agents","year":2024,"lang":"en","type":"article","venue":"Bioorganic Chemistry","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut Universitaire de Cardiologie et de Pneumologie de Québec; Université Laval","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Canada Foundation for Innovation","keywords":"Chemistry; Moiety; Stereochemistry; Tubulin; Cytotoxicity; IC50; In vitro; Microtubule; Cell growth; Cell culture; Biochemistry; Cell biology; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002235174,0.0003686638,0.0002945963,0.0001816476,0.0001246093,0.0001633273,0.0002500427,0.000258909,0.0006040236],"category_scores_gemma":[0.0001203705,0.0001473084,0.0001786635,0.0001400377,0.0001669058,0.000179987,0.0001334728,0.0002847986,0.0002093437],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002374627,"about_ca_system_score_gemma":0.0002706644,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004807122,"about_ca_topic_score_gemma":0.0009582791,"domain_scores_codex":[0.9998925,0.00002621309,0.00001080966,0.00001862693,0.00002636324,0.00002554487],"domain_scores_gemma":[0.9999164,0.000007713232,0.00002929066,0.000005362903,0.00001669371,0.00002446729],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001143974,0.00005999357,0.0001717875,0.0001095058,0.000007477254,0.00009310809,0.00002879445,0.0005205965,0.9952376,0.0002248928,0.00004369843,0.003388163],"study_design_scores_gemma":[0.00006519928,0.00195899,0.001285633,0.00001000419,0.00002383682,0.0001846977,0.00002414885,0.0007310394,0.9896309,0.00003548486,0.006038851,0.00001113703],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9846283,0.006037252,0.006440022,0.000101037,0.00003805583,0.0001939198,0.0003166652,0.00006429886,0.002180467],"genre_scores_gemma":[0.9824941,0.004392292,0.01037904,0.00006611166,0.00001674762,0.0001182206,0.0003864288,0.00001258998,0.002134607],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006040236,"threshold_uncertainty_score":0.002020717,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09063553742453592,"score_gpt":0.309264895478073,"score_spread":0.2186293580535371,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}