{"id":"W4392987439","doi":"10.3390/biology13030196","title":"Engineering a Dual Specificity γδ T-Cell Receptor for Cancer Immunotherapy","year":2024,"lang":"en","type":"article","venue":"Biology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Food Inspection Agency; Leucid Bio","keywords":"Biology; T-cell receptor; Cancer immunotherapy; Cytotoxic T cell; Immunotherapy; Cytolysis; Antigen; Cancer research; T cell; Immunology; Molecular biology; Virology; Immune system; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001305724,0.0003777823,0.0002263064,0.0001798561,0.00009303755,0.0004366535,0.0003006424,0.000519869,0.001006582],"category_scores_gemma":[0.0001008504,0.0001342197,0.0001957297,0.0001965762,0.0001586963,0.0002368958,0.0003049004,0.0007084787,0.0006140109],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002096219,"about_ca_system_score_gemma":0.0001301232,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001725739,"about_ca_topic_score_gemma":0.0002476205,"domain_scores_codex":[0.9998015,0.00004199671,0.00001419087,0.00003163446,0.00005285608,0.00005792838],"domain_scores_gemma":[0.999957,0.000006866362,0.00001343539,0.00000602386,0.000006611135,0.00001016166],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000454467,0.00003472067,0.00006789197,0.00002791781,0.000003673385,0.00003823311,0.00001166293,0.0002523556,0.9973482,0.0001609874,0.00002832054,0.001980585],"study_design_scores_gemma":[0.00003848209,0.0005490301,0.0005202807,0.000006521619,0.00002685041,0.0004936954,0.00002121689,0.002183076,0.9906597,0.00007478803,0.005419694,0.00000670967],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9728745,0.002227894,0.02185209,0.0001265329,0.00005418405,0.0001358506,0.0001271746,0.0001383267,0.002463565],"genre_scores_gemma":[0.9882092,0.0007312525,0.00942645,0.00006813809,0.000008421023,0.00003738672,0.0001065413,0.00001666256,0.001395868],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001006582,"threshold_uncertainty_score":0.003367305,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03771093852680156,"score_gpt":0.3449318331504315,"score_spread":0.3072208946236299,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}