{"id":"W4393013367","doi":"10.26420/austinjclinopthalmol.2023.1144","title":"Ligand-Independent Activation of Platelet-Derived Growth Factor Receptor β Promotes Contraction of Retinal Pigment Epithelial Cells","year":2023,"lang":"en","type":"article","venue":"Austin Journal of Clinical Ophthalmology ","topic":"Retinal and Macular Surgery","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Natural Science Foundation of Tianjin City; Sanming Project of Medicine in Shenzhen; Shanxi Scholarship Council of China; National Natural Science Foundation of China; Health Commission of Shanxi Province","keywords":"Proliferative vitreoretinopathy; Cell biology; Protein kinase B; Platelet-derived growth factor receptor; PI3K/AKT/mTOR pathway; Growth factor; Platelet-derived growth factor; Chemistry; Cancer research; Signal transduction; Biology; Retinal; Receptor; Retinal detachment; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002257637,0.0001738977,0.001197743,0.0002444363,0.00003145371,0.000005055019,0.000139823,0.0003258329,0.0003531109],"category_scores_gemma":[0.003733907,0.0001300021,0.0005240707,0.0002400859,0.0001941866,0.00009849747,0.00005222495,0.000664358,0.00002653597],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003303533,"about_ca_system_score_gemma":0.0002923388,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002145875,"about_ca_topic_score_gemma":1.0583e-7,"domain_scores_codex":[0.9963014,0.0003756414,0.002289895,0.0002189622,0.0005543123,0.0002598134],"domain_scores_gemma":[0.9946208,0.00191307,0.002295239,0.0001653088,0.0007921548,0.0002134344],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006633239,0.0007585164,0.05752497,0.0002378377,0.0003711028,0.0008059986,0.0001167854,0.00001788564,0.9283989,0.00003130118,0.0004390626,0.004664388],"study_design_scores_gemma":[0.002513409,0.004447099,0.2829088,0.0003303279,0.0001249403,0.00156892,0.000099402,0.00002951127,0.7073591,0.0002615919,0.0002558245,0.000101091],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996557,0.00002583618,0.0002155974,0.001294559,0.001432764,0.0002722751,0.00001587436,0.00001233265,0.0001737546],"genre_scores_gemma":[0.9982175,0.0002239212,0.0006897779,0.00003909082,0.0005742892,0.000003050138,0.00001281434,0.00002116515,0.0002183647],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2253838,"threshold_uncertainty_score":0.5301333,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08325459358983459,"score_gpt":0.3802821794024849,"score_spread":0.2970275858126503,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}