{"id":"W4393013367","doi":"10.26420/austinjclinopthalmol.2023.1144","title":"Ligand-Independent Activation of Platelet-Derived Growth Factor Receptor β Promotes Contraction of Retinal Pigment Epithelial Cells","year":2023,"lang":"en","type":"article","venue":"Austin Journal of Clinical Ophthalmology ","topic":"Retinal and Macular Surgery","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Natural Science Foundation of Tianjin City; Sanming Project of Medicine in Shenzhen; Shanxi Scholarship Council of China; National Natural Science Foundation of China; Health Commission of Shanxi Province","keywords":"Proliferative vitreoretinopathy; Cell biology; Protein kinase B; Platelet-derived growth factor receptor; PI3K/AKT/mTOR pathway; Growth factor; Platelet-derived growth factor; Chemistry; Cancer research; Signal transduction; Biology; Retinal; Receptor; Retinal detachment; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000100659,0.0001828498,0.0001764195,0.0001276095,0.0000934608,0.0001733677,0.00008938155,0.0001723338,0.001293889],"category_scores_gemma":[0.00009708115,0.00007351201,0.0002854325,0.00008167339,0.0001019124,0.00009307294,0.0001488724,0.00054104,0.0003575681],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001076056,"about_ca_system_score_gemma":0.000120358,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001839024,"about_ca_topic_score_gemma":0.0002322779,"domain_scores_codex":[0.9998722,0.00002013722,0.00001252891,0.00002082779,0.00004301253,0.00003124034],"domain_scores_gemma":[0.9999354,0.000009778971,0.00001832907,0.000009908898,0.000008659394,0.00001780874],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00016503,0.00005194307,0.000393214,0.00006793474,0.000008462251,0.0001674715,0.00001431152,0.00002403511,0.9970556,0.00006037086,0.0001635543,0.00182812],"study_design_scores_gemma":[0.00006627628,0.0008533099,0.03581142,0.00001850793,0.00004401566,0.001732774,0.00008947848,0.00110997,0.9527907,0.0001035051,0.007373353,0.000006507559],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920611,0.003375153,0.001595097,0.0001714237,0.00007556939,0.0000314784,0.0003275202,0.0000788393,0.002283731],"genre_scores_gemma":[0.9964461,0.001061404,0.0005174633,0.00009989901,0.00001680787,0.00003664363,0.0003538461,0.000008554563,0.001459389],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001293889,"threshold_uncertainty_score":0.004328489,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08325459358983459,"score_gpt":0.3802821794024849,"score_spread":0.2970275858126503,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}