{"id":"W4393015884","doi":"10.1002/ajh.27283","title":"Benefit of axicabtagene ciloleucel versus chemoimmunotherapy in older patients and/or patients with poor <scp>ECOG</scp> performance status with relapsed or refractory large B‐cell lymphoma after 2 or more lines of prior therapy","year":2024,"lang":"en","type":"article","venue":"American Journal of Hematology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; Office of Naval Research; bluebird bio; Pharmacyclics; Daiichi Sankyo Europe; Takeda Oncology; AstraZeneca; Genentech; Adaptive Biotechnologies; Health Resources and Services Administration; National Institutes of Health; MorphoSys; Seagen; CareDx; BeiGene; Swedish Orphan Biovitrum; Astellas Pharma; GlaxoSmithKline; Kiadis Pharma; Sanofi; TG Therapeutics; Medac; Ipsen; Jazz Pharmaceuticals; Boston Scientific Corporation; StemCyte; U.S. Navy; Legend Biotech; HistoGenetics; Omeros Corporation; Vertex Pharmaceuticals; Leukemia and Lymphoma Society; U.S. Department of Defense; Celgene; CSL Behring; Bristol-Myers Squibb; Amgen; National Heart, Lung, and Blood Institute; Ascentage Pharma; Novartis Pharmaceuticals Corporation; Incyte; Pfizer; Mallinckrodt Pharmaceuticals; Society for Immunotherapy of Cancer; Astellas Pharma US; Atara Biotherapeutics; Actinium Pharmaceuticals; National Cancer Institute; Gilead Sciences","keywords":"Chemoimmunotherapy; Medicine; Internal medicine; Hazard ratio; Refractory (planetary science); Propensity score matching; Lymphoma; Regimen; Salvage therapy; Gastroenterology; Surgery; Oncology; Chemotherapy; Confidence interval; Rituximab","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007744476,0.0001625027,0.0004673408,0.0001939004,0.0001011675,0.0003210773,0.0001426114,0.0002227305,0.0008779308],"category_scores_gemma":[0.001133558,0.00009385421,0.0005288512,0.0001778101,0.0001590407,0.0002801212,0.0002168203,0.0003712274,0.00007997994],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003205845,"about_ca_system_score_gemma":0.0002359736,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000449275,"about_ca_topic_score_gemma":0.001435274,"domain_scores_codex":[0.9997213,0.0001532681,0.00002102493,0.00004139809,0.0000227445,0.00004018789],"domain_scores_gemma":[0.9994313,0.0001698058,0.0002033234,0.00002693845,0.00001355071,0.0001549809],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.4269887,0.004317544,0.4073295,0.0004386521,0.002559791,0.0003809935,0.0001493898,0.002139545,0.009910084,0.0002285,0.00104049,0.1445167],"study_design_scores_gemma":[0.02908988,0.1347145,0.8225567,0.00008068407,0.002714337,0.0006774701,0.0001827593,0.004498424,0.002265774,0.0002557145,0.002930567,0.00003326238],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983767,0.001209826,0.00003503976,0.00005270712,0.00001503946,0.00001163875,0.0000445333,0.000002727191,0.0002516658],"genre_scores_gemma":[0.9994385,0.0002461981,0.00003841788,0.00005699354,0.00003201606,0.000008350042,0.00008669303,6.056439e-7,0.00009226506],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008779308,"threshold_uncertainty_score":0.004095674,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01006108526489442,"score_gpt":0.2739395781119439,"score_spread":0.2638784928470495,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}