{"id":"W4393018283","doi":"10.1101/2024.03.18.585495","title":"14-3-3ζ regulates adipogenesis by modulating chromatin accessibility during the early stages of adipocyte differentiation","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"14-3-3 protein interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute for Research in Immunology and Cancer; Centre Hospitalier de l’Université de Montréal; McGill University; Montreal Neurological Institute and Hospital; Université de Montréal","funders":"Fonds de recherche du Québec – Nature et technologies; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Genome Canada; Mitacs; University of Oxford; National Institutes of Health; Medical Research Council; American Diabetes Association","keywords":"Adipogenesis; Chromatin; Cell biology; Adipocyte; Adipose tissue; Biology; Chromatin remodeling; Interactome; Regulator; Gene; Endocrinology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004631944,0.0005443697,0.0004527124,0.0001413649,0.0002261822,0.0002599896,0.0007277852,0.0005778308,0.00005317402],"category_scores_gemma":[0.0003384933,0.0004840225,0.0002921277,0.0002903917,0.0001660759,0.00001992795,0.001281772,0.0005987675,0.0000153635],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001613137,"about_ca_system_score_gemma":0.0002345573,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001567556,"about_ca_topic_score_gemma":0.0000107826,"domain_scores_codex":[0.9970269,0.0002466778,0.0007828312,0.00113465,0.0003737237,0.0004352252],"domain_scores_gemma":[0.9969511,0.00004509265,0.0007000674,0.001723053,0.0004553398,0.0001253462],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003943729,0.00007622105,0.01711087,0.0007716047,0.0004384786,0.000002540126,0.00001469788,0.0001338108,0.9812145,0.00001946763,0.0001734657,0.000004907822],"study_design_scores_gemma":[0.0001739857,0.00003919976,0.2484774,0.0003105205,0.0001419192,2.447441e-8,0.000002469195,0.0001868229,0.7501448,0.000005428808,0.0001575689,0.0003598573],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928928,0.004340989,0.0003450825,0.00009315525,0.00072809,0.0008273457,0.0006333517,0.0001321623,0.000007007473],"genre_scores_gemma":[0.9979901,0.0001713812,0.0008484641,0.00002075168,0.0004171933,0.000336166,0.000004740969,0.0001451485,0.00006602048],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2313665,"threshold_uncertainty_score":0.9997612,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007389337551055211,"score_gpt":0.2266168349227637,"score_spread":0.2192274973717085,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}