{"id":"W4393022960","doi":"10.1101/2024.03.12.584681","title":"Widespread variation in molecular interactions and regulatory properties among transcription factor isoforms","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sinai Health System; Lunenfeld-Tanenbaum Research Institute; University of Toronto","funders":"Wallonie-Bruxelles International; Université de Liège; Fonds De La Recherche Scientifique - FNRS; National Institutes of Health; Andrew Sabin Family Foundation; Melanoma Research Alliance; University of Texas MD Anderson Cancer Center; Cancer Prevention and Research Institute of Texas; Fonds Léon Fredericq; Charles A. King Trust; Belgian American Educational Foundation","keywords":"Gene isoform; Transcription factor; Gene; Biology; Effector; Subcellular localization; Computational biology; DNA; Alternative splicing; Regulation of gene expression; Genetics; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005275239,0.0001597973,0.0002497456,0.0008630485,0.0001984268,0.0003673629,0.0002096439,0.0002208027,0.0007174395],"category_scores_gemma":[0.000982899,0.0001491647,0.0002502027,0.0006193432,0.0003503906,0.0002241117,0.0002656319,0.0002598604,0.0002724085],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001420622,"about_ca_system_score_gemma":0.00007559891,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000374486,"about_ca_topic_score_gemma":0.0006048662,"domain_scores_codex":[0.9993131,0.00009123489,0.00007032305,0.0003211174,0.0001463362,0.00005797639],"domain_scores_gemma":[0.998939,0.0003817898,0.0003079164,0.0001973117,0.0001015244,0.00007237002],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002590728,0.00001502724,0.05824557,0.00005186819,0.00009426926,0.00009851644,0.0001241565,0.0001422871,0.9335565,0.0001480703,0.00005240788,0.00721229],"study_design_scores_gemma":[0.00001155203,0.0001548296,0.8531537,0.00001101391,0.0001292108,0.00187274,0.0001849223,0.001063884,0.1405097,0.0006510471,0.002235224,0.00002214418],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961332,0.0007288706,0.002135265,0.00001482058,0.000004247292,0.000005996203,0.000436,0.00002487003,0.000516719],"genre_scores_gemma":[0.9972622,0.000226659,0.001422973,0.0000297574,0.000006818012,0.00001059682,0.0007115735,0.00002638752,0.0003029956],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008630485,"threshold_uncertainty_score":0.002789855,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007957093239831112,"score_gpt":0.1953985926770569,"score_spread":0.1874414994372258,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}