{"id":"W4393024692","doi":"10.1002/alz.13779","title":"Age of Alzheimer's disease diagnosis in people with Down syndrome and associated factors: Results from the Horizon 21 European Down syndrome consortium","year":2024,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Down syndrome and intellectual disability research","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Trinity College","funders":"National Institute on Aging; Instituto de Salud Carlos III; Medical Research Council; National Institutes of Health; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas; National Institute for Health and Care Research; Generalitat de Catalunya; NIHR Cambridge Biomedical Research Centre; European Regional Development Fund; European Commission; University College London; Fundación Tatiana Pérez de Guzmán el Bueno; Horizon 2020 Framework Programme; Else Kröner-Fresenius-Stiftung; Fondation Jérôme Lejeune; National Institute for Health Research Applied Research Collaboration East of England; Health Research Board; Department of Health and Social Care; Global Brain Health Institute; Wellcome Trust","keywords":"Disease; Medicine; Down syndrome; Pediatrics; Alzheimer's disease; Age groups; Age of onset; Gerontology; Psychiatry; Demography; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001639474,0.0002394135,0.0004106776,0.002032228,0.0003135082,0.0007249733,0.0003251319,0.0003245958,0.0008433002],"category_scores_gemma":[0.004219537,0.0001337798,0.0007735954,0.002192413,0.000175477,0.0003483609,0.0007241357,0.0002555465,0.0001839423],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006311,"about_ca_system_score_gemma":0.0004613804,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.04749471,"about_ca_topic_score_gemma":0.04104002,"domain_scores_codex":[0.9990238,0.0002587067,0.0001988716,0.0001426727,0.0002659268,0.0001099518],"domain_scores_gemma":[0.9966155,0.0005015252,0.001659241,0.0001208612,0.0007692713,0.0003336294],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00008327762,0.000006191468,0.9976034,0.00003729374,0.00008403281,0.00003174571,0.0000655257,0.00004377613,0.00002504727,0.0000144852,0.0004030427,0.001602333],"study_design_scores_gemma":[0.000003604493,0.00001990398,0.9993686,0.00002406037,0.00002854214,0.00006745319,0.00007195675,0.00001808557,0.0000176449,0.000006222503,0.0003715295,0.000002329774],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9798661,0.002647997,0.0001192913,0.0001526023,0.00002596441,0.00003685707,0.01488052,0.00001031698,0.00226041],"genre_scores_gemma":[0.98792,0.0009083248,0.0001688223,0.00007072624,0.00001865033,0.0000392546,0.01048984,0.000003695897,0.0003806257],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04749471,"threshold_uncertainty_score":0.09443653,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0365806234328879,"score_gpt":0.2846096765689174,"score_spread":0.2480290531360295,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}