{"id":"W4393028887","doi":"10.1371/journal.pone.0300337","title":"mTORC1 is required for differentiation of germline stem cells in the Drosophila melanogaster testis","year":2024,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Neurobiology and Insect Physiology Research","field":"Neuroscience","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; University of California, Los Angeles; National Institutes of Health; Seoul National University; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California Los Angeles; National Institute on Aging; Deutsches Krebsforschungszentrum; University of Toronto; University of Minnesota","keywords":"Germline; Biology; Stem cell; mTORC1; Cell biology; Somatic cell; Cellular differentiation; PI3K/AKT/mTOR pathway; Germ cell; RNA interference; Adult stem cell; Genetics; Signal transduction; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008284987,0.000403854,0.000279331,0.0004383353,0.0004007807,0.0003651555,0.0002640361,0.0002602137,0.001851243],"category_scores_gemma":[0.00009801721,0.0002572661,0.0002103872,0.0001705542,0.0002613017,0.000186606,0.0003412508,0.0004348738,0.0008612646],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006003069,"about_ca_system_score_gemma":0.0004030758,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002190276,"about_ca_topic_score_gemma":0.005768596,"domain_scores_codex":[0.9998734,0.00001253868,0.0000187592,0.0000365106,0.00004035302,0.00001837322],"domain_scores_gemma":[0.999822,0.00001578891,0.00006838874,0.00001081512,0.00001658955,0.0000665378],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003896599,0.000005256211,0.000427062,0.00004960108,0.000004413343,0.0001859474,0.00001289634,0.00004828693,0.9982061,0.0001407234,0.00009405776,0.0007866398],"study_design_scores_gemma":[0.00003038613,0.00008354175,0.07193418,0.00002442074,0.0000361284,0.001076376,0.0001059513,0.00186723,0.9158047,0.0001351535,0.008882527,0.00001947539],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9865633,0.003532131,0.002383001,0.0001828058,0.00005159885,0.00003753739,0.002998289,0.0002922421,0.003959028],"genre_scores_gemma":[0.9909875,0.0008261966,0.001378275,0.00008562329,0.0000113716,0.00002841214,0.001969947,0.000101354,0.00461143],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002190276,"threshold_uncertainty_score":0.006192982,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1124809091560525,"score_gpt":0.2947578338169189,"score_spread":0.1822769246608664,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}