{"id":"W4393031552","doi":"10.1038/s42003-024-06017-8","title":"Endothelial gene regulatory elements associated with cardiopharyngeal lineage differentiation","year":2024,"lang":"en","type":"article","venue":"Communications Biology","topic":"Congenital heart defects research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; Ministero dell’Istruzione, dell’Università e della Ricerca; Fondazione Telethon; Fondation Leducq","keywords":"Mesoderm; Enhancer; Biology; Transcription factor; FGF and mesoderm formation; Lateral plate mesoderm; Genetics; Computational biology; Regulation of gene expression; Chromatin; Cell biology; Gene; Embryonic stem cell","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001803713,0.0001827522,0.0001721886,0.0002769328,0.0001294465,0.0002306195,0.0001775322,0.0001694151,0.001184578],"category_scores_gemma":[0.000512741,0.0001508297,0.0003118035,0.000292567,0.0001197682,0.0001392231,0.000147893,0.0002603686,0.0001890188],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000200844,"about_ca_system_score_gemma":0.0002972205,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001761957,"about_ca_topic_score_gemma":0.003226458,"domain_scores_codex":[0.9998975,0.00001437618,0.000005152017,0.00004654897,0.00002452383,0.00001188967],"domain_scores_gemma":[0.9998325,0.00008337785,0.00003089471,0.00001546835,0.00002653373,0.00001117427],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005029717,0.0002387112,0.1698544,0.000514928,0.0001488949,0.000354975,0.0001362448,0.2421436,0.5059714,0.003854502,0.001236562,0.07504281],"study_design_scores_gemma":[0.00003842527,0.0001512844,0.1528141,0.00003739192,0.0001071306,0.0002780365,0.00006470098,0.6522188,0.1870867,0.002919867,0.004253834,0.00002971025],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9571022,0.0002604322,0.03845235,0.00004237546,0.000009161899,0.00001972244,0.002187291,0.0003501692,0.001576224],"genre_scores_gemma":[0.9765351,0.0001481565,0.0184716,0.00002387927,0.000003070271,0.00002501581,0.004121915,0.00004670948,0.0006246594],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001761957,"threshold_uncertainty_score":0.003962815,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02475249956814273,"score_gpt":0.3175767926955826,"score_spread":0.2928242931274398,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}