{"id":"W4393038504","doi":"10.1186/s12981-024-00604-9","title":"Efficacy and safety of switching to dolutegravir/lamivudine in virologically suppressed people with HIV-1 aged ≥ 50 years: week 48 pooled results from the TANGO and SALSA studies","year":2024,"lang":"en","type":"article","venue":"AIDS Research and Therapy","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"ViiV Healthcare","keywords":"Dolutegravir; Medicine; Lamivudine; Regimen; Adverse effect; Population; Internal medicine; Human immunodeficiency virus (HIV); Viral load; Immunology; Antiretroviral therapy; Virus; Environmental health","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01447709,0.001265562,0.003996374,0.001920564,0.0003219932,0.001762138,0.000791279,0.001142613,0.002513605],"category_scores_gemma":[0.01401251,0.0006411884,0.01392038,0.001455303,0.0005770351,0.0008194193,0.001053244,0.001028398,0.0002501367],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009439614,"about_ca_system_score_gemma":0.0008952551,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003019759,"about_ca_topic_score_gemma":0.006623015,"domain_scores_codex":[0.9925756,0.004211927,0.00116806,0.0008703333,0.0008706675,0.000303414],"domain_scores_gemma":[0.9870645,0.005496083,0.005178853,0.0009512818,0.0008595976,0.0004496457],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"observational","study_design_scores_codex":[0.3031465,0.0005971382,0.1644972,0.01672751,0.4395927,0.0002264393,0.0007077528,0.001794936,0.002914837,0.0001226851,0.002010432,0.06766178],"study_design_scores_gemma":[0.05253562,0.02236508,0.4770358,0.004165377,0.4367146,0.0003848903,0.000330843,0.0009182016,0.001370026,0.0003902003,0.003604491,0.0001849078],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8478877,0.1403596,0.0008082552,0.0003274575,0.0001662808,0.0008000056,0.006796618,0.00007584348,0.002778288],"genre_scores_gemma":[0.9878791,0.00858136,0.0004418478,0.0002676538,0.0001380634,0.0004107774,0.001876608,0.00001704041,0.0003875415],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01447709,"threshold_uncertainty_score":0.07656306,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05169452181347262,"score_gpt":0.3484135252042578,"score_spread":0.2967190033907852,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}