{"id":"W4393042773","doi":"10.14740/wjon1818","title":"Characterization of Asciminib-Resistant Philadelphia Chromosome-Positive Cells","year":2024,"lang":"en","type":"article","venue":"World Journal of Oncology","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Ponatinib; Medicine; Myeloid leukemia; Philadelphia chromosome; Dasatinib; Mutation; Chronic myelogenous leukemia; Cancer research; Tyrosine kinase; Leukemia; Gene; Immunology; Internal medicine; Genetics; Imatinib; Receptor; Biology; Chromosomal translocation","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001278896,0.0002158049,0.0001520684,0.0005769694,0.0002107281,0.0002610828,0.000167033,0.0002738227,0.001872794],"category_scores_gemma":[0.0001690599,0.00008205113,0.0001486161,0.0004214544,0.000142744,0.000160557,0.0002217054,0.0003556604,0.0007413423],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001404006,"about_ca_system_score_gemma":0.0001191153,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003104426,"about_ca_topic_score_gemma":0.0003170378,"domain_scores_codex":[0.9998329,0.00001778792,0.00002236846,0.0000395436,0.00006171115,0.00002559153],"domain_scores_gemma":[0.9998209,0.00002928971,0.00003402303,0.00003337759,0.00005063854,0.00003185751],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002425363,0.00007355982,0.008205292,0.0000731231,0.00001489944,0.0008726215,0.0001396155,0.0001022705,0.9809302,0.0002751123,0.0003471461,0.008723678],"study_design_scores_gemma":[0.0001144753,0.001375468,0.09400322,0.00002639218,0.0001188548,0.01466508,0.0003392537,0.003793156,0.8589123,0.0004898255,0.02613821,0.00002383339],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9782698,0.00204404,0.01111594,0.0002546491,0.00005216821,0.0003177887,0.002191327,0.0001719865,0.0055823],"genre_scores_gemma":[0.9809237,0.001019032,0.008756397,0.0001478961,0.00002799543,0.0002867396,0.004751418,0.00004109316,0.004045887],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001872794,"threshold_uncertainty_score":0.006265163,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01792819775070128,"score_gpt":0.3035361825343758,"score_spread":0.2856079847836745,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}