{"id":"W4393050140","doi":"10.21037/tau-23-620","title":"Biomarker challenges in the pursuit of personalized neoadjuvant chemotherapy for muscle-invasive bladder cancer: conclusions from SWOG S1314","year":2024,"lang":"en","type":"editorial","venue":"Translational Andrology and Urology","topic":"Bladder and Urothelial Cancer Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"National Cancer Institute","keywords":"Bladder cancer; Medicine; Biomarker; Chemotherapy; Oncology; Neoadjuvant therapy; Internal medicine; Cancer; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003270486,0.0003327155,0.0008204436,0.0001640676,0.00009059184,0.000009145547,0.0001950986,0.001048952,0.0004856512],"category_scores_gemma":[0.0000493658,0.0002265284,0.0002280871,0.00009015906,0.0004734851,0.00002946538,0.00002249738,0.0005422548,0.000003444683],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002022689,"about_ca_system_score_gemma":0.0006122378,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000376781,"about_ca_topic_score_gemma":0.001317799,"domain_scores_codex":[0.9981779,0.0001643582,0.0004072363,0.0005932371,0.0003562306,0.000301058],"domain_scores_gemma":[0.9970195,0.002502131,0.0001180524,0.000189571,0.0001086491,0.00006207557],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.02835136,0.001492759,0.002729441,0.00151846,0.008701986,0.000347329,0.02480795,0.00002162992,0.002041501,0.004825054,0.8310961,0.0940665],"study_design_scores_gemma":[0.0111276,0.001482505,0.01037663,0.00009930573,0.001631526,0.00003062463,0.0001322544,0.0001203394,0.00002438129,0.01507613,0.9596658,0.000232861],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.03204272,0.4821851,0.0001963806,0.2102634,0.2558621,0.004046236,0.01311148,0.0000907765,0.002201806],"genre_scores_gemma":[0.4531996,0.1894117,0.0004137631,0.009177525,0.3362823,0.002629594,0.007462167,0.000247679,0.001175572],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.4211569,"threshold_uncertainty_score":0.9237558,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04069251304856288,"score_gpt":0.3288504559733891,"score_spread":0.2881579429248263,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}