{"id":"W4393052939","doi":"10.1007/s00125-024-06123-6","title":"Differential CpG methylation at Nnat in the early establishment of beta cell heterogeneity","year":2024,"lang":"en","type":"article","venue":"Diabetologia","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; McGill University","funders":"Institute of Nutrition, Metabolism and Diabetes; Medical Research Council; Fonds de Recherche du Québec - Santé; National Institute of Diabetes and Digestive and Kidney Diseases; NIHR Imperial Biomedical Research Centre; National Institutes of Health; Division of Diabetes, Endocrinology, and Metabolic Diseases; National Institute for Health and Care Research; European Association for the Study of Diabetes; Society for Endocrinology; Canadian Institutes of Health Research; Wellcome Trust; Fondation du CHUM; California Institute for Regenerative Medicine","keywords":"Biology; DNA methylation; Population; Epigenomics; CpG site; DNA methyltransferase; Molecular biology; Epigenetics; Beta cell; Cell biology; Gene expression; Genetics; Gene; Insulin; Islet; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001845764,0.00013245,0.0002230637,0.0002194,0.0001411785,0.000379503,0.0001451393,0.0002036257,0.001641623],"category_scores_gemma":[0.000190487,0.0002028217,0.0001874759,0.0001494561,0.0002195339,0.0001891183,0.0003095212,0.0003373565,0.0003996912],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002347192,"about_ca_system_score_gemma":0.0001633302,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001172335,"about_ca_topic_score_gemma":0.00280825,"domain_scores_codex":[0.9998732,0.00001048341,0.000007191722,0.00005974324,0.00002925924,0.00002018773],"domain_scores_gemma":[0.9998512,0.00002947172,0.00004537292,0.00001751646,0.00002585786,0.00003042721],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007606875,0.000004126392,0.003142833,0.00002199684,0.000007144086,0.00002515716,0.000032355,0.00008066831,0.9949663,0.0000883929,0.00003802239,0.001516982],"study_design_scores_gemma":[0.00001715848,0.0001568577,0.3730175,0.00002673952,0.00005912484,0.0003733503,0.0001565899,0.004609944,0.6163128,0.000465209,0.004781771,0.00002291788],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884799,0.001128568,0.007488743,0.00006446223,0.00002130884,0.00001782171,0.001009006,0.000158198,0.001632073],"genre_scores_gemma":[0.9947022,0.0003669038,0.002517266,0.00005926996,0.000007721325,0.00002459769,0.0005617358,0.00005740369,0.001702899],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001641623,"threshold_uncertainty_score":0.005491793,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02175209387137936,"score_gpt":0.2712428101912969,"score_spread":0.2494907163199175,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}