{"id":"W4393054377","doi":"10.3389/fonc.2024.1346502","title":"Phase 1, first-in-human study of TYRP1-TCB (RO7293583), a novel TYRP1-targeting CD3 T-cell engager, in metastatic melanoma: active drug monitoring to assess the impact of immune response on drug exposure","year":2024,"lang":"en","type":"article","venue":"Frontiers in Oncology","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"National Cancer Institute","keywords":"Medicine; Melanoma; Tolerability; Pharmacokinetics; Drug; Pembrolizumab; Adverse effect; Rash; Dosing; Immune system; Pharmacology; Immunotherapy; Oncology; Cancer research; Immunology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003630485,0.000310683,0.001103316,0.001135675,0.0001005032,0.00001679493,0.0003879123,0.0001029596,0.00004350027],"category_scores_gemma":[0.0007119828,0.0002167123,0.0002138675,0.00101818,0.0001490597,0.00009402783,0.0001900292,0.001291092,0.000004253642],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009700805,"about_ca_system_score_gemma":0.0005340407,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003877566,"about_ca_topic_score_gemma":0.0003558763,"domain_scores_codex":[0.9961823,0.001262214,0.0009777576,0.0004932816,0.0004964067,0.0005880838],"domain_scores_gemma":[0.9966083,0.002590523,0.0001879898,0.0003659039,0.0001086962,0.0001385718],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0926357,0.03717247,0.3909945,0.001345409,0.001508859,0.004516052,0.1887845,0.004894732,0.2518989,0.00005375644,0.008219549,0.01797559],"study_design_scores_gemma":[0.04333103,0.04627105,0.6361963,0.002563695,0.0003817067,0.00007545505,0.1632725,0.006043908,0.09684395,0.0002554563,0.003772522,0.0009924278],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940224,0.002458673,0.0000484304,0.0007741987,0.0006220152,0.001522485,0.0000484544,0.00001741093,0.000485962],"genre_scores_gemma":[0.9975086,0.0001275784,0.001111447,0.00002052886,0.0001107987,0.00018239,0.00001301555,0.00004229074,0.0008832926],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2452018,"threshold_uncertainty_score":0.8837273,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05279081540121635,"score_gpt":0.4166276137492951,"score_spread":0.3638367983480788,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}