{"id":"W4393054442","doi":"10.3389/fmed.2024.1369136","title":"Targeting KRAS mutations in pancreatic cancer: opportunities for future strategies","year":2024,"lang":"en","type":"article","venue":"Frontiers in Medicine","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"KRAS; Cancer research; Pancreatic cancer; Carcinogenesis; Neuroblastoma RAS viral oncogene homolog; Molecular oncology; Biology; Stromal cell; MAPK/ERK pathway; Cancer; Signal transduction; Medicine; Genetics; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002449189,0.0006913801,0.001361394,0.001071528,0.0003650183,0.002174373,0.001011874,0.001989624,0.008468511],"category_scores_gemma":[0.001328358,0.0002859012,0.0009600812,0.0005791622,0.001394753,0.003450194,0.001337708,0.00506546,0.002349263],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000880929,"about_ca_system_score_gemma":0.001471879,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004657899,"about_ca_topic_score_gemma":0.00186639,"domain_scores_codex":[0.9995079,0.0001516404,0.00003883802,0.00006358731,0.0001263506,0.0001116824],"domain_scores_gemma":[0.9989642,0.0004979158,0.00008543304,0.00004175285,0.0002246692,0.0001859827],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000676411,0.0005105614,0.0005617653,0.006276719,0.0001419263,0.0008473131,0.0002495642,0.001091116,0.007840678,0.02611691,0.07523675,0.8804502],"study_design_scores_gemma":[0.0001470486,0.0009766128,0.0009810922,0.003242363,0.0001793915,0.001565926,0.0003841323,0.0008496988,0.001990665,0.02572446,0.9638948,0.00006382381],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001426903,0.9721236,0.00258626,0.0185761,0.001199918,0.00002663572,0.00006931589,0.0001080526,0.003883237],"genre_scores_gemma":[0.009785441,0.9749463,0.003283492,0.005687969,0.003247848,0.00006333626,0.0001531479,0.00003138989,0.002801108],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.008468511,"threshold_uncertainty_score":0.02832997,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06065112926298041,"score_gpt":0.3790415388749272,"score_spread":0.3183904096119468,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}