{"id":"W4393054442","doi":"10.3389/fmed.2024.1369136","title":"Targeting KRAS mutations in pancreatic cancer: opportunities for future strategies","year":2024,"lang":"en","type":"article","venue":"Frontiers in Medicine","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"KRAS; Cancer research; Pancreatic cancer; Carcinogenesis; Neuroblastoma RAS viral oncogene homolog; Molecular oncology; Biology; Stromal cell; MAPK/ERK pathway; Cancer; Signal transduction; Medicine; Genetics; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008162893,0.0001623365,0.0007464199,0.0006119247,0.00005770537,0.00001681276,0.00009193723,0.0001404495,0.0002549645],"category_scores_gemma":[0.0002683056,0.0001221023,0.00004635143,0.0004329836,0.0003371745,0.0001301094,0.00001512865,0.0003791991,0.000002369006],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002827105,"about_ca_system_score_gemma":0.0008768449,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003498985,"about_ca_topic_score_gemma":0.0001054013,"domain_scores_codex":[0.9985451,0.00007477693,0.0004455737,0.0002759611,0.000263042,0.0003956087],"domain_scores_gemma":[0.9993387,0.0002769605,0.00003914612,0.0001422867,0.00007905684,0.0001238443],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"qualitative","study_design_scores_codex":[0.0007406089,0.0001809125,0.5196637,0.004191327,0.0005628012,0.001821591,0.02088283,0.0001381942,0.0007040208,0.007163896,0.3946713,0.04927886],"study_design_scores_gemma":[0.01042277,0.002025332,0.1470289,0.008666151,0.001449734,0.0001137231,0.4543056,0.1303676,0.00004717615,0.02566426,0.2192506,0.0006581233],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.764209,0.112535,0.02760009,0.0730888,0.004432792,0.002576736,0.00006376355,0.0002009951,0.01529279],"genre_scores_gemma":[0.9376383,0.02313258,0.02383074,0.001045614,0.003215141,0.001397059,0.0003938409,0.0000750843,0.009271638],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4334227,"threshold_uncertainty_score":0.4979188,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06065112926298041,"score_gpt":0.3790415388749272,"score_spread":0.3183904096119468,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}