{"id":"W4393055235","doi":"10.1093/braincomms/fcae096","title":"Hippocampal hyperphosphorylated tau-induced deficiency is rescued by L-type calcium channel blockade","year":2024,"lang":"en","type":"article","venue":"Brain Communications","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland","funders":"National Institute on Aging; Canadian Institutes of Health Research; Alzheimer's Society; Alzheimer Society Research Program; National Institutes of Health; Takeda Science Foundation","keywords":"Hippocampal formation; Hippocampus; Hyperphosphorylation; Internal medicine; Endocrinology; Amino acid; Calcium channel; Calcium; Chemistry; Human brain; Tau protein; Voltage-dependent calcium channel; Neuroscience; Alzheimer's disease; Biology; Phosphorylation; Medicine; Biochemistry; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001356818,0.0005732815,0.0006442364,0.0002957095,0.0001815429,0.000359594,0.0004671995,0.0004232212,0.001066127],"category_scores_gemma":[0.0001807785,0.0001637141,0.0004201987,0.0001816784,0.000342363,0.0003078634,0.0002206735,0.0009218016,0.0003027961],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002908472,"about_ca_system_score_gemma":0.0004374218,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001158615,"about_ca_topic_score_gemma":0.001952515,"domain_scores_codex":[0.9998449,0.00001438595,0.00002024014,0.00003097357,0.0000372461,0.0000522427],"domain_scores_gemma":[0.9997783,0.00002410835,0.00008620204,0.00002856172,0.00002272091,0.00006010531],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005845201,0.0001974184,0.0001500287,0.00005393841,0.00001465508,0.0001553094,0.0000316943,0.0001221907,0.9965665,0.00007465524,0.00006294665,0.001986106],"study_design_scores_gemma":[0.0001705275,0.003142188,0.002867452,0.00001992926,0.00005024757,0.0005278394,0.00005622166,0.001416385,0.9899446,0.0001037768,0.00168864,0.00001225697],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973737,0.0006669406,0.0008030498,0.00007788165,0.00004363831,0.00003752097,0.0002189543,0.0001109688,0.0006674217],"genre_scores_gemma":[0.994931,0.001132861,0.001381497,0.00005287915,0.00001729201,0.00007783664,0.0004374013,0.00002656251,0.001942468],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001158615,"threshold_uncertainty_score":0.003566504,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08070410020099772,"score_gpt":0.3742616013023897,"score_spread":0.2935575011013919,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}