{"id":"W4393057611","doi":"10.1182/blood.2024023983","title":"Genetic regulation of carnitine metabolism controls lipid damage repair and aging RBC hemolysis in vivo and in vitro","year":2024,"lang":"en","type":"article","venue":"Blood","topic":"Metabolism and Genetic Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria; University of British Columbia","funders":"National Institute of General Medical Sciences; National Cancer Institute; National Heart, Lung, and Blood Institute; National Institutes of Health","keywords":"Carnitine; Hemolysis; Biology; In vivo; Lipid metabolism; Genome-wide association study; Biochemistry; Genetics; Single-nucleotide polymorphism; Immunology; Gene; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000315624,0.0002334428,0.0001604269,0.0002818728,0.000139481,0.0002580797,0.0001485502,0.0001945789,0.001136391],"category_scores_gemma":[0.0002915448,0.0001454591,0.0001584905,0.0001921593,0.0002300149,0.0000961609,0.0001841651,0.0001670021,0.0001268227],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002331923,"about_ca_system_score_gemma":0.0001391079,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001153234,"about_ca_topic_score_gemma":0.001236231,"domain_scores_codex":[0.9997705,0.0000786914,0.00002060278,0.00007271728,0.00003147333,0.00002610338],"domain_scores_gemma":[0.9997175,0.00004762891,0.0001178578,0.00004408712,0.00002590122,0.00004702924],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001388979,0.00009327164,0.04048489,0.00002719057,0.00008007582,0.00008966801,0.0001052378,0.00009777806,0.9554858,0.00007694687,0.00006814665,0.002002042],"study_design_scores_gemma":[0.00005542251,0.0007611084,0.7689989,0.00001635273,0.0001486675,0.0006412045,0.0001430657,0.001890592,0.2264573,0.0001534576,0.0007192024,0.00001486281],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992152,0.0001867461,0.0003796354,0.0000136602,0.000003350932,0.000003969086,0.0001046618,0.000006016178,0.00008671194],"genre_scores_gemma":[0.9993033,0.00007662566,0.0002758399,0.00001395063,0.000001915558,0.00000788892,0.0001055086,0.000005649976,0.0002093622],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001153234,"threshold_uncertainty_score":0.003801584,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003495869740861723,"score_gpt":0.2101472877424517,"score_spread":0.20665141800159,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}