{"id":"W4393057611","doi":"10.1182/blood.2024023983","title":"Genetic regulation of carnitine metabolism controls lipid damage repair and aging RBC hemolysis in vivo and in vitro","year":2024,"lang":"en","type":"article","venue":"Blood","topic":"Metabolism and Genetic Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria; University of British Columbia","funders":"National Institute of General Medical Sciences; National Cancer Institute; National Heart, Lung, and Blood Institute; National Institutes of Health","keywords":"Carnitine; Hemolysis; Biology; In vivo; Lipid metabolism; Genome-wide association study; Biochemistry; Genetics; Single-nucleotide polymorphism; Immunology; Gene; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001971446,0.0001135908,0.000208753,0.0001229255,0.00001434848,0.00001870359,0.00004906092,0.00007991679,0.00001008359],"category_scores_gemma":[0.00004985935,0.0001119269,0.00004560213,0.0001395138,0.00005847136,0.000004409063,0.00005919665,0.00005313015,3.134236e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":9.087549e-7,"about_ca_system_score_gemma":0.00002618972,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007591807,"about_ca_topic_score_gemma":0.00009348264,"domain_scores_codex":[0.9991581,0.00006957196,0.0002403837,0.0003063057,0.00007719899,0.0001484099],"domain_scores_gemma":[0.9997064,0.00001737858,0.00003654,0.0001803916,0.00002017832,0.00003906658],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003814229,0.00005467272,0.009960678,0.00009100321,0.000048641,0.000005973994,0.0001264818,0.00003737002,0.9857417,0.00003487286,0.00002078837,0.003839688],"study_design_scores_gemma":[0.003138206,0.00005147651,0.2763993,0.00005989543,0.0002153576,0.00002144086,0.0001521849,0.00148591,0.711282,0.0002840604,0.006656893,0.0002532201],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9684775,0.03085267,0.0000622112,0.00006600797,0.00004837464,0.0001475161,0.00002117846,0.000009230847,0.0003153283],"genre_scores_gemma":[0.9972566,0.001395004,0.001027006,0.00004655295,0.00009381289,0.000016515,0.0000175956,0.00001451973,0.0001323307],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2744597,"threshold_uncertainty_score":0.4564247,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003495869740861723,"score_gpt":0.2101472877424517,"score_spread":0.20665141800159,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}