{"id":"W4393059054","doi":"10.1080/17474124.2024.2326838","title":"Histologic assessments in ulcerative colitis: the evidence behind a new endpoint in clinical trials","year":2024,"lang":"en","type":"article","venue":"Expert Review of Gastroenterology & Hepatology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Pfizer Japan; Eli Lilly Japan; Allergan; Genentech; Mitsubishi Tanabe Pharma Corporation; Celltrion; Boston Pharmaceuticals; Bristol-Myers Squibb; Eli Lilly and Company; AstraZeneca; Celltrion Healthcare; Pfizer; Kyorin Pharmaceutical; EA Pharma Co., Ltd.; Gilead Sciences; Amgen","keywords":"Medicine; Ulcerative colitis; Inflammatory bowel disease; Clinical trial; Colectomy; Colorectal cancer; Disease; Internal medicine; Clinical endpoint; Microscopic colitis; Colonoscopy; Gastroenterology; Surrogate endpoint; Pathology; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006241301,0.0002846725,0.001187785,0.0001185109,0.00002753657,0.00001180709,0.0005198468,0.0002743673,0.0002156597],"category_scores_gemma":[0.002776438,0.0002027496,0.0004439741,0.00009685227,0.000422229,0.00001537459,0.0002482741,0.0004291087,0.00002175876],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008573516,"about_ca_system_score_gemma":0.000544848,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009113536,"about_ca_topic_score_gemma":0.003041177,"domain_scores_codex":[0.9893653,0.007198018,0.002079426,0.0007237776,0.000149228,0.0004842859],"domain_scores_gemma":[0.9983341,0.0004791837,0.000393293,0.00060183,0.00006876692,0.0001228402],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0100644,0.0006165258,0.8619492,0.002558811,0.0005628782,0.002828644,0.0004726631,0.000006778259,0.002493777,0.0009055407,0.09531359,0.02222717],"study_design_scores_gemma":[0.004508815,0.004609944,0.8656771,0.01138337,0.0002882377,0.0007200937,0.0001940427,0.0004824463,0.0005076043,0.0006409295,0.1103972,0.0005903075],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8443594,0.1439745,0.0008372789,0.007895096,0.001258961,0.001489836,0.00002611061,0.0000186193,0.0001402621],"genre_scores_gemma":[0.8704603,0.1171399,0.0005398054,0.01097773,0.0003175021,0.0003825151,0.00005835555,0.00002635052,0.00009750423],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02683453,"threshold_uncertainty_score":0.8267887,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08193311081722345,"score_gpt":0.4517310636249114,"score_spread":0.369797952807688,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}