{"id":"W4393064580","doi":"10.1021/acs.jafc.3c09716","title":"Prunin from <i>Poncirus trifoliata</i> (L.) Rafin Inhibits Aldose Reductase and Glucose-Fructose–Mediated Protein Glycation and Oxidation of Human Serum Albumin","year":2024,"lang":"en","type":"article","venue":"Journal of Agricultural and Food Chemistry","topic":"Advanced Glycation End Products research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; University of Calgary","funders":"","keywords":"Aldose reductase; Glycation; Chemistry; Human serum albumin; Biochemistry; Fructose; Naringin; Serum albumin; Glycosylation; Aldose reductase inhibitor; Chromatography; Enzyme; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00015654,0.0001446982,0.000176018,0.00002953925,0.00005942991,0.00004857281,0.00008295838,0.000134315,0.000008962475],"category_scores_gemma":[0.0001403383,0.0001010956,0.00003857569,0.0001298349,0.00009820805,0.00003966552,0.00007178287,0.0001921394,2.967144e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001612133,"about_ca_system_score_gemma":0.00005515564,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006938807,"about_ca_topic_score_gemma":0.000003232875,"domain_scores_codex":[0.9990562,0.00003614878,0.0003509326,0.0002495907,0.0001793505,0.0001277578],"domain_scores_gemma":[0.9993322,0.00001939477,0.000215248,0.000101929,0.0002107264,0.0001204541],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006594463,0.00003406197,0.00007505574,0.0001830703,0.00007288487,0.000001889866,0.000122811,0.000002040823,0.9968871,0.000008663539,0.0003177703,0.002228703],"study_design_scores_gemma":[0.0006603342,0.0003037998,0.004546443,0.0001447721,0.00003343309,0.0001274257,0.0002974148,0.000003422254,0.9924339,0.0001486044,0.001168724,0.0001316932],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9866722,0.01235206,0.00001297278,0.0006631385,0.00003061306,0.0001398967,0.00008493374,0.000006244562,0.00003790821],"genre_scores_gemma":[0.9976575,0.001097906,0.0003205697,0.0000123427,0.0003250597,0.00000525253,0.0002603127,0.000009388472,0.0003116626],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01125416,"threshold_uncertainty_score":0.4122559,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008982028759555291,"score_gpt":0.2454241380409854,"score_spread":0.2364421092814301,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}