{"id":"W4393064580","doi":"10.1021/acs.jafc.3c09716","title":"Prunin from <i>Poncirus trifoliata</i> (L.) Rafin Inhibits Aldose Reductase and Glucose-Fructose–Mediated Protein Glycation and Oxidation of Human Serum Albumin","year":2024,"lang":"en","type":"article","venue":"Journal of Agricultural and Food Chemistry","topic":"Advanced Glycation End Products research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; University of Calgary","funders":"","keywords":"Aldose reductase; Glycation; Chemistry; Human serum albumin; Biochemistry; Fructose; Naringin; Serum albumin; Glycosylation; Aldose reductase inhibitor; Chromatography; Enzyme; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007099428,0.0003245992,0.0002364817,0.0002507623,0.0001206378,0.0001406282,0.0001924705,0.0001853796,0.0008743202],"category_scores_gemma":[0.00009079279,0.0000949244,0.0002784225,0.0001254475,0.00013927,0.0001341172,0.0001148879,0.0003196888,0.0002129633],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002177752,"about_ca_system_score_gemma":0.0001228182,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001611332,"about_ca_topic_score_gemma":0.001453205,"domain_scores_codex":[0.9999542,0.000009247203,0.000003124664,0.000007663035,0.00001084856,0.00001486067],"domain_scores_gemma":[0.9999548,0.000008611187,0.00001604865,0.000002214917,0.000005812739,0.00001241767],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001311083,0.00002837946,0.0001067341,0.00004693274,0.000008601595,0.00004066958,0.000006165842,0.00008743816,0.9984697,0.00003399254,0.00004189064,0.0009983975],"study_design_scores_gemma":[0.00007293061,0.001179334,0.009578698,0.00001091043,0.00005965151,0.0007062138,0.00003577496,0.001680071,0.9825416,0.00006800493,0.004054921,0.00001188782],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99507,0.001501945,0.001616827,0.0001113915,0.0000184763,0.00002723547,0.0002317418,0.0001053987,0.001316994],"genre_scores_gemma":[0.9950932,0.0006419726,0.002014101,0.00008183836,0.00000843653,0.00001235167,0.0007811658,0.00001652985,0.001350366],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001611332,"threshold_uncertainty_score":0.003203928,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008982028759555291,"score_gpt":0.2454241380409854,"score_spread":0.2364421092814301,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}