{"id":"W4393066507","doi":"10.1038/s42003-024-06035-6","title":"A genetic mouse model of lean-NAFLD unveils sexual dimorphism in the liver-heart axis","year":2024,"lang":"en","type":"article","venue":"Communications Biology","topic":"Liver Disease Diagnosis and Treatment","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital Maisonneuve-Rosemont; Université de Montréal; University of Ottawa; Montreal Heart Institute","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Institut de Cardiologie de Montréal; Fondation Institut de Cardiologie de Montréal; Government of Canada; Heart and Stroke Foundation of Canada","keywords":"Internal medicine; Endocrinology; Sexual dimorphism; Steatosis; Obesity; Medicine; Biology; Metabolic syndrome; Diastole; Blood pressure","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000416325,0.0006036797,0.0003893215,0.001649317,0.0003590156,0.0004953903,0.0003685756,0.0006801958,0.006844329],"category_scores_gemma":[0.00020906,0.0004173027,0.0003582269,0.0004316488,0.0005872818,0.0004300522,0.0003804255,0.001389651,0.0009207259],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002665828,"about_ca_system_score_gemma":0.0003393226,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003280465,"about_ca_topic_score_gemma":0.001101512,"domain_scores_codex":[0.9996167,0.00006936527,0.00005276483,0.0001004868,0.00009822108,0.00006240889],"domain_scores_gemma":[0.99962,0.00004891002,0.0001330455,0.00005168422,0.00003007173,0.0001163535],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000848603,0.0003968935,0.001799344,0.0000956299,0.00002479336,0.0005337151,0.00009948034,0.0001101848,0.989087,0.001956093,0.0002987089,0.004749584],"study_design_scores_gemma":[0.0005895499,0.003602341,0.04494214,0.0001846126,0.0002296165,0.007360665,0.0005562411,0.003630972,0.9033928,0.003106788,0.03232162,0.00008276457],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9745182,0.001409665,0.01438764,0.0006783677,0.0002075743,0.0001161933,0.003335834,0.0004427651,0.004903763],"genre_scores_gemma":[0.9612863,0.001800133,0.01407123,0.0004281452,0.00005896726,0.0003882384,0.002478963,0.0002775384,0.01921048],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006844329,"threshold_uncertainty_score":0.02289659,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08678379037920096,"score_gpt":0.3408422062670396,"score_spread":0.2540584158878387,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}