{"id":"W4393068335","doi":"10.1101/2024.03.18.585604","title":"The PRC2.1 Subcomplex Opposes G1 Progression through Regulation of CCND1 and CCND2","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"University of California, San Francisco; National Institutes of Health","keywords":"PRC2; Cyclin D1; Cell cycle; Cell biology; Biology; Palbociclib; Cancer research; Genetics; Gene; Epigenetics; EZH2; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004176873,0.0004773766,0.0006309864,0.0001315005,0.0001881218,0.0001185888,0.0002567415,0.0003476202,0.00002078513],"category_scores_gemma":[0.0001348814,0.0003510918,0.0001418989,0.0003775925,0.0004739899,0.000118382,0.0006061122,0.0007226135,0.00001221095],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002231977,"about_ca_system_score_gemma":0.0005398387,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002352024,"about_ca_topic_score_gemma":0.000002028839,"domain_scores_codex":[0.997634,0.00009567777,0.0005380179,0.0007924541,0.0005312008,0.000408677],"domain_scores_gemma":[0.9976037,0.0001198121,0.0004618979,0.001159242,0.0005070219,0.0001483083],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00057799,0.0001693924,0.004064033,0.00292599,0.0005720147,0.00004269551,0.0001023813,0.00001616368,0.982299,0.008372528,0.0004416625,0.0004161701],"study_design_scores_gemma":[0.001812643,0.0003329556,0.1928923,0.006742042,0.0005614436,4.949765e-7,0.00003210253,0.0005640629,0.7291023,0.0005716017,0.06648195,0.0009060439],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9415721,0.05087306,0.0006555703,0.002912813,0.001304842,0.001940351,0.0001401231,0.0005488556,0.00005233979],"genre_scores_gemma":[0.9894392,0.001224903,0.008278724,0.00009541639,0.0005582312,0.0002257554,6.49081e-7,0.0001496638,0.0000273856],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2531967,"threshold_uncertainty_score":0.9998941,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02104715557265041,"score_gpt":0.2828120964709319,"score_spread":0.2617649408982815,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}