{"id":"W4393071888","doi":"10.1158/1538-7445.am2024-2914","title":"Abstract 2914: AI/ML-driven discovery of CTHRC1, collagen triple helix repeat-containing 1, a novel proteoglycan for stroma + tumor targeting and delivery of 4-1BB costimulation","year":2024,"lang":"en","type":"article","venue":"Cancer Research","topic":"Radiomics and Machine Learning in Medical Imaging","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Public Health Ontario","funders":"","keywords":"Stroma; Triple helix; Medicine; Proteoglycan; Cancer research; Chemistry; Immunology; Anatomy; Cartilage; Stereochemistry; Immunohistochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002240004,0.0002879628,0.0001499719,0.0002910069,0.0001437732,0.0003040489,0.0002130841,0.0002304869,0.001404103],"category_scores_gemma":[0.0001003293,0.0001089342,0.0001620395,0.0001699239,0.0001424224,0.00009259739,0.000161004,0.0003820254,0.0005282369],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000609158,"about_ca_system_score_gemma":0.0004055782,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007947448,"about_ca_topic_score_gemma":0.001655374,"domain_scores_codex":[0.9998877,0.00001078933,0.000004770642,0.00002161287,0.00005431267,0.00002073441],"domain_scores_gemma":[0.9999284,0.000008095714,0.00001988301,0.000004588886,0.00001365747,0.00002531208],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004175006,0.00001808115,0.0001897685,0.00001908557,0.000003232645,0.00004268563,0.000004482022,0.0002919073,0.9974695,0.0001118854,0.0001640667,0.001643633],"study_design_scores_gemma":[0.00002206251,0.0002805265,0.001809931,0.000003175751,0.0000137684,0.0002272087,0.000011428,0.002865059,0.989913,0.00004674505,0.004803458,0.000003586182],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9804686,0.001339028,0.01033054,0.0003178336,0.00004759792,0.0002235802,0.002335155,0.0002325467,0.004705125],"genre_scores_gemma":[0.9647467,0.001061948,0.01963848,0.0001842409,0.00001923258,0.0001088013,0.004026365,0.00005990509,0.01015446],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001404103,"threshold_uncertainty_score":0.004697204,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05112483774378429,"score_gpt":0.4076410583531972,"score_spread":0.3565162206094129,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}