{"id":"W4393073073","doi":"10.1158/1538-7445.am2024-7061","title":"Abstract 7061: Targeting metabolic vulnerabilities in ARID1A/B dual-deficient dedifferentiated endometrial carcinoma","year":2024,"lang":"en","type":"article","venue":"Cancer Research","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Spinal Cord Injury BC; University of British Columbia","funders":"","keywords":"ARID1A; Medicine; Endometrial cancer; Cancer research; Carcinoma; Oncology; Internal medicine; Biology; Cancer; Gene; Genetics; Mutation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001285903,0.0001660279,0.0002086749,0.0003279877,0.0001226514,0.0001433603,0.0002021395,0.0001530453,0.0003157381],"category_scores_gemma":[0.0003774819,0.0001458878,0.000115117,0.0006191076,0.0001373195,0.000007071503,0.0001581167,0.0005045021,0.00002739692],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001355672,"about_ca_system_score_gemma":0.0005261786,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00142779,"about_ca_topic_score_gemma":0.0002388884,"domain_scores_codex":[0.9978288,0.0001674298,0.0003300146,0.0005829621,0.0004840507,0.0006067315],"domain_scores_gemma":[0.9992859,0.0001085782,0.000026074,0.00029317,0.0001822074,0.0001040324],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001541892,0.00005985202,0.00159437,0.0002193532,0.00005700562,0.00002553958,0.0003761335,0.001064776,0.9836324,0.0001620905,0.004768518,0.007885751],"study_design_scores_gemma":[0.001504807,0.0001897468,0.005901631,0.0002292206,0.00002145448,0.000008757684,0.000767731,0.002503913,0.9383698,0.0003533546,0.04970805,0.0004415661],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9457547,0.05234038,0.00005073173,0.0001830915,0.0006869955,0.0002536854,0.00006023105,0.00002970019,0.0006404931],"genre_scores_gemma":[0.996058,0.00180253,0.00004525749,0.00002306621,0.001030319,0.0001992406,0.00009325615,0.00004016493,0.0007081132],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05053785,"threshold_uncertainty_score":0.5949131,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05861144684577816,"score_gpt":0.3806741623172644,"score_spread":0.3220627154714862,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}