{"id":"W4393073289","doi":"10.1158/1538-7445.am2024-4236","title":"Abstract 4236: PDX-derived organoids (PDXO) are valuable tools to unveil the shortcomings of new anti-cancer drug candidates","year":2024,"lang":"en","type":"article","venue":"Cancer Research","topic":"Fluorine in Organic Chemistry","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Micropharma (Canada)","funders":"","keywords":"Organoid; Cancer; Drug; Medicine; Biology; Computational biology; Pharmacology; Oncology; Cancer research; Internal medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009707719,0.0005960092,0.0005129446,0.0004427822,0.0002987162,0.001159122,0.0004179273,0.0005485825,0.004376527],"category_scores_gemma":[0.0003902644,0.0002237707,0.0003662877,0.0003358247,0.0004345913,0.0006852049,0.0006648207,0.001330615,0.001939059],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005525985,"about_ca_system_score_gemma":0.0003312092,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004253075,"about_ca_topic_score_gemma":0.0005333791,"domain_scores_codex":[0.9996599,0.00008138073,0.00003587361,0.00007966578,0.0001117067,0.0000315723],"domain_scores_gemma":[0.9995031,0.0001338476,0.0001222165,0.00009823062,0.00007719959,0.00006531095],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003047074,0.00008378431,0.001096463,0.0003732056,0.00002540889,0.0001559818,0.00005303071,0.0006056445,0.980352,0.0009452687,0.001449964,0.01455449],"study_design_scores_gemma":[0.00004029034,0.0009346863,0.005270257,0.00005931691,0.00005335944,0.0008729675,0.00007849884,0.001637233,0.9511407,0.0004873883,0.03940615,0.00001914885],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8087311,0.03116488,0.1147229,0.002610898,0.0008238615,0.0008134606,0.01798185,0.002317387,0.02083365],"genre_scores_gemma":[0.9194972,0.009748529,0.04375073,0.0006822355,0.00009239792,0.0004359163,0.01422425,0.0003464246,0.01122222],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004376527,"threshold_uncertainty_score":0.01464093,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2661781804108691,"score_gpt":0.5349383879298936,"score_spread":0.2687602075190245,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}