{"id":"W4393073512","doi":"10.1038/s41467-024-46559-3","title":"Diindoles produced from commensal microbiota metabolites function as endogenous CAR/Nr1i3 ligands","year":2024,"lang":"en","type":"article","venue":"Nature Communications","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University; University of Toronto","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Natural Sciences and Engineering Research Council of Canada; University of Illinois at Urbana-Champaign; Canadian Institutes of Health Research; American Cancer Society; Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada; National Cancer Institute; National Institutes of Health; U.S. Department of Health and Human Services; Government of Canada; Agence Nationale de la Recherche","keywords":"Nuclear receptor; Microbiome; Biology; Human microbiome; Computational biology; Function (biology); Bacteria; Receptor; Host (biology); Gene; Cell biology; Genetics; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001537423,0.0001939705,0.0001320013,0.0001447733,0.00007911208,0.0001668964,0.000166635,0.0001790034,0.001488107],"category_scores_gemma":[0.000115825,0.00008330485,0.0001495457,0.00006709884,0.0001393853,0.0001257558,0.0001484269,0.0002745102,0.0004198716],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001835202,"about_ca_system_score_gemma":0.00009436682,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001557297,"about_ca_topic_score_gemma":0.0005544694,"domain_scores_codex":[0.9999001,0.00002873569,0.000005582735,0.00001864518,0.00002809011,0.00001877223],"domain_scores_gemma":[0.9999261,0.00001791076,0.00002359916,0.000008511391,0.000008716465,0.00001517056],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008347972,0.00001000167,0.0001770091,0.00004067968,0.000003800646,0.00003632917,0.000007854353,0.0000387279,0.9973062,0.0001092781,0.00003577004,0.002150791],"study_design_scores_gemma":[0.00001029655,0.000371359,0.001973309,0.00000581027,0.000007245356,0.0003045718,0.00002623247,0.0002839995,0.9928237,0.00004156036,0.004147994,0.000003876163],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9724647,0.009907156,0.01013277,0.0002384642,0.00005380148,0.00005596966,0.0005054979,0.0001360494,0.006505576],"genre_scores_gemma":[0.9864547,0.002990993,0.006661007,0.0001777434,0.00001593313,0.00004388103,0.0004564148,0.00002133478,0.003178013],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001488107,"threshold_uncertainty_score":0.00497824,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1193947992279688,"score_gpt":0.4313304683252504,"score_spread":0.3119356690972817,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}