{"id":"W4393076484","doi":"10.1158/1538-7445.am2024-1533","title":"Abstract 1533: Characterizing tumor-immune surveillance in Li-Fraumeni syndrome","year":2024,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Li–Fraumeni syndrome; Immune system; Medicine; Cancer; Immunology; Biology; Internal medicine; Genetics; Mutation; Germline mutation; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002375238,0.0004247131,0.0002466092,0.001098272,0.0001558398,0.0001594272,0.0001629404,0.0004245797,0.001878067],"category_scores_gemma":[0.0002862157,0.00009910716,0.0002039708,0.0002958663,0.0003016335,0.0001475399,0.0001965472,0.0003341419,0.0003450867],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000197331,"about_ca_system_score_gemma":0.0001117099,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007065628,"about_ca_topic_score_gemma":0.0004546417,"domain_scores_codex":[0.9998728,0.00002234654,0.00001470632,0.00002865284,0.00003485133,0.00002672591],"domain_scores_gemma":[0.9998385,0.00004803654,0.00003401175,0.00001265683,0.00001892189,0.00004787172],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002680793,0.0000386262,0.01273781,0.00005340877,0.00001187904,0.00247937,0.00006117907,0.000098998,0.9805222,0.00009636004,0.00009071598,0.003541298],"study_design_scores_gemma":[0.00007206354,0.001651058,0.1963073,0.00002879213,0.0001039117,0.04585164,0.000191095,0.0028441,0.7471289,0.0003937101,0.005403792,0.00002369221],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996678,0.0006998825,0.00150431,0.00004731648,0.00000742862,0.00002294119,0.0003166705,0.00003493207,0.0006884659],"genre_scores_gemma":[0.9977239,0.0002541962,0.001112201,0.00003258319,0.00000694402,0.00001692342,0.0003809649,0.00001419915,0.0004581056],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001878067,"threshold_uncertainty_score":0.006282687,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05991527616478999,"score_gpt":0.3872837382212071,"score_spread":0.3273684620564171,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}