{"id":"W4393084941","doi":"10.1158/1538-7445.am2024-6716","title":"Abstract 6716: DLL3 TriTCE Co-Stim: A next generation trispecific T cell engager with integrated CD28 costimulation for the treatment of DLL3-expressing cancers","year":2024,"lang":"en","type":"article","venue":"Cancer Research","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Zymeworks (Canada)","funders":"","keywords":"Cancer research; Medicine; Cell; Cancer; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009624392,0.0002945272,0.0001360125,0.0001459583,0.00008102556,0.0002108087,0.0002377418,0.0003203459,0.002238653],"category_scores_gemma":[0.00005544249,0.000086611,0.0001924498,0.0001026282,0.00009654837,0.000147686,0.0002626888,0.0004671488,0.0009141671],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003121703,"about_ca_system_score_gemma":0.0001975096,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000439806,"about_ca_topic_score_gemma":0.0005935958,"domain_scores_codex":[0.9999188,0.000009641223,0.000004738393,0.00001416189,0.00002782102,0.00002479328],"domain_scores_gemma":[0.9999729,0.000002078392,0.000007575619,0.000001942021,0.000005337428,0.00001009599],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000136489,0.00006451552,0.0001826864,0.00006296389,0.00001048865,0.00007286907,0.00001561716,0.0005188555,0.9910421,0.0002680129,0.000718131,0.006907268],"study_design_scores_gemma":[0.00004932347,0.0006687363,0.0008353718,0.000008797888,0.00002254219,0.0004228189,0.00001764078,0.00333881,0.9812851,0.0000820477,0.01325904,0.000009694359],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9570035,0.005635891,0.02364799,0.0006033101,0.0001716471,0.0001851225,0.0009131245,0.0005984643,0.01124094],"genre_scores_gemma":[0.9796686,0.001738338,0.009687583,0.0003264085,0.00002393088,0.0001239627,0.000700894,0.00005584612,0.00767459],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002238653,"threshold_uncertainty_score":0.007489085,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2988560671214947,"score_gpt":0.4732763836450434,"score_spread":0.1744203165235487,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}