{"id":"W4393085476","doi":"10.1158/1538-7445.am2024-5898","title":"Abstract 5898: Inhibition of the LONP1 ATPase domain induces mitochondrial proteotoxic stress and is cytotoxic to acute myeloid leukemia cells","year":2024,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Myeloid leukemia; Cytotoxic T cell; Biology; Cancer research; Leukemia; Apoptosis; Myeloid; Mitochondrion; Cell biology; Immunology; In vitro; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001682992,0.0003655036,0.0004946468,0.0002855158,0.0001896319,0.0003329863,0.0002357149,0.0002534597,0.003471286],"category_scores_gemma":[0.0001597606,0.0001307324,0.0003144404,0.0004510769,0.0001750929,0.0001481003,0.000164473,0.000596199,0.0008539013],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002413899,"about_ca_system_score_gemma":0.0002510972,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005742977,"about_ca_topic_score_gemma":0.0006895333,"domain_scores_codex":[0.9997846,0.00002149853,0.00003004956,0.000049517,0.00007268379,0.00004159018],"domain_scores_gemma":[0.9998755,0.00002352685,0.000037173,0.00001707524,0.00001367739,0.00003294527],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006961344,0.00009869449,0.0006077693,0.0001569911,0.00003121395,0.0001082682,0.00001518702,0.0002208173,0.9929003,0.00009168639,0.001439027,0.003634003],"study_design_scores_gemma":[0.0001298497,0.0007841349,0.01039357,0.00001964279,0.00005319799,0.000532925,0.00004067664,0.002456119,0.9739579,0.00007736226,0.01154573,0.000008917807],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9747195,0.002785423,0.002417199,0.0004921461,0.0002084744,0.00008586574,0.01617191,0.0006644882,0.002455012],"genre_scores_gemma":[0.9682102,0.001359329,0.002602899,0.0001937659,0.00002799449,0.0001275434,0.02396637,0.00009006078,0.003421877],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003471286,"threshold_uncertainty_score":0.01161259,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02315632725990341,"score_gpt":0.3320852902083091,"score_spread":0.3089289629484057,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}