{"id":"W4393085897","doi":"10.1158/1538-7445.am2024-6139","title":"Abstract 6139: Genetic modifiers of KRAS-mutant colorectal cancer","year":2024,"lang":"en","type":"article","venue":"Cancer Research","topic":"Colorectal Cancer Treatments and Studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland; University of Toronto","funders":"","keywords":"KRAS; Colorectal cancer; Cancer; Mutant; Medicine; Oncology; Cancer research; Biology; Internal medicine; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005428492,0.0005770046,0.0005226012,0.001340458,0.0007608544,0.0005782416,0.0005505045,0.0008207588,0.01168623],"category_scores_gemma":[0.001936658,0.0001842573,0.001164276,0.001678012,0.0002954682,0.0002211908,0.0005019188,0.0006834349,0.00139315],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003146344,"about_ca_system_score_gemma":0.0004536324,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004645513,"about_ca_topic_score_gemma":0.00471245,"domain_scores_codex":[0.9993663,0.00008903469,0.00006915715,0.0002632173,0.0001260935,0.0000861823],"domain_scores_gemma":[0.9991112,0.0003354367,0.0002543727,0.00008547838,0.00007139998,0.0001421359],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004441482,0.0002558483,0.8020816,0.0005304806,0.001390254,0.009444775,0.0003082989,0.002282636,0.1327228,0.002279488,0.005651998,0.03861026],"study_design_scores_gemma":[0.000250845,0.0004999908,0.9613155,0.0001001751,0.00119582,0.006564728,0.0001187998,0.003888961,0.012601,0.001390788,0.01202382,0.00004956574],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9783503,0.001637751,0.003591362,0.000322488,0.000140139,0.00008008336,0.01296824,0.0001953585,0.002714245],"genre_scores_gemma":[0.9918126,0.0002197469,0.002138944,0.0001230381,0.00006235508,0.00004587369,0.004088564,0.00007833396,0.001430573],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01168623,"threshold_uncertainty_score":0.03909433,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09137930213570061,"score_gpt":0.4431309045804164,"score_spread":0.3517516024447158,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}